Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201600550
Keywords
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Funding
- Italian Association for Cancer Research [IG 14565]
- MIUR grant PRIN [2012SK7ASN]
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A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.
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