Journal
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Volume -, Issue -, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-023-28659-7
Keywords
Nitrogen oxides; Nitrogen dioxide; Particulate matter; Alcohol drinking; Liver enzymes
Categories
Ask authors/readers for more resources
Evidence on the association between exposure to air pollution and liver enzymes was lacking in low pollution areas. This cross-sectional study aimed to investigate this association and explored the influence of alcohol intake. The results showed that long-term low-level exposure to PM2.5, PM10, NOx, and NO2 was significantly associated with elevated levels of liver enzymes. Moreover, alcohol consumption exacerbated the effect of air pollution on liver enzymes.
Evidences on the association between exposure to air pollution and liver enzymes was scarce in low pollution area. We aimed to investigate the association between air pollution and liver enzyme levels and further explore whether alcohol intake influence this association. This cross-sectional study included 425,773 participants aged 37 to 73 years from the UK Biobank. Land Use Regression was applied to assess levels of PM2.5, PM10, NO2, and NOx. Levels of liver enzymes including AST, ALT, GGT, and ALP were determined by enzymatic rate method. Long-term low-level exposure to PM2.5 (per 5-& mu;g/m(3) increase) was significantly associated with AST (0.596% increase, 95% CI, 0.414 to 0.778%), ALT (0.311% increase, 0.031 to 0.593%), and GGT (1.552% increase, 1.172 to 1.933%); The results were similar for PM10; NOX and NO2 were only significantly correlated with AST and GGT Significant modification effects by alcohol consumption were found (P-interaction < 0.05). The effects of pollutants on AST, ALT, and GGT levels gradually increased along with the weekly alcohol drinking frequency. In conclusion, long-term low-level air pollutants exposure was associated with elevated liver enzyme levels. And alcohol intake may exacerbate the effect of air pollution on liver enzymes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available