Journal
ACS MACRO LETTERS
Volume 5, Issue 8, Pages 936-941Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.6b00459
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Funding
- Electron Microscopy of Soft Matter Program from the Office of Basic Energy Sciences of the U.S. Department of Energy [DE-AC02-05CH11231]
- National Institutes of Health (NIH) [1R01CA194533, 1R41CA183327]
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We introduce the use of block copolymer membranes for an emerging application, drug capture. The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxonibicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.
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