Journal
ACS MACRO LETTERS
Volume 5, Issue 11, Pages 1222-1226Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.6b00750
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Funding
- National Natural Science Foundation of China (NSFC) [21074058, 51473079]
- National Basic Research Program of China (973 Program) [2012CB821500]
- key technologies R&D program of Tianjin [14ZCZDSF00007]
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Hydrogels containing protein components are a type of promising biomaterial. In this paper, we designed triple responsive polymer-protein networks based on molecular recognition. Reduced bovine serum albumin (BSA) was modified with multiple beta-cyclodextrin (beta CD) by thiol-disulfide exchange reaction. The beta CD-modified BSA was added into the aqueous solution of acrylamide copolymer with pendant adamantyl groups, resulting in the formation of polymer-protein network structures. The assembled polymer networks show triple-responsive behaviors upon treatment with trypsin, reduced glutathione, or native beta CD. The network structures may find applications in tissue engineering and drug controlled release.
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