Effects of running a marathon on sclerostin and parathyroid hormone concentration in males aged over 50

The aim of our study was to verify whether running a marathon (32nd Wroclaw Marathon) was associated with changes in sclerostin and intact PTH (iPTH) concentration in middle-aged males. We enrolled 33 males who completed the marathon race. Blood samples were taken 60 minutes before (V1), immediately after (V2), and 7 days after the run (V3). The mean serum sclerostin concentration was 42.4 & PLUSMN; 10.8 pmol/L at V1, increased to 62.9 & PLUSMN; 12.6 pmol/L at V2 (t= -11.206; p < 0.001) and returned to baseline in V3 (t = 8.344; p < 0.001, V3 vs. V2). A similar trend was recorded for iPTH (t= -7.440; p < 0.001, for V2 vs. V1; t = 6.229; p < 0.001, for V3 vs. V2), at V3, iPTH levels remained significantly higher than V1 (t= -2.759; p = 0.010). The results of our study suggest that, in middle-aged males, running a marathon affects skeletal metabolism by activating two counteracting mechanisms, although temporarily overlapping: first, by a sudden inhibition of bone formation, through induction sclerostin expression and, secondly, by a long-lasting induction of PTH, which also guarantees the maintenance of adequate circulating levels of calcium. The net effect would be the maintenance of adequately high levels of circulating calcium to be used for neuromuscular activity and muscle contraction.

Automated summary

The aim of this study was to investigate the impact of running a marathon on sclerostin and intact PTH concentration in middle-aged males. The results showed that the levels of serum sclerostin and iPTH increased immediately after the marathon race but returned to baseline after 7 days. It was suggested that running a marathon affected skeletal metabolism by inhibiting bone formation through sclerostin expression and inducing long-lasting PTH elevation to maintain adequate calcium levels for neuromuscular activity and muscle contraction.