The interaction between miRNAs and hazardous materials

Toxic agents are broadly present in the environment, households, and workplaces. Contamination of food and drinking water with these agents results in entry of these materials to the body. The crosstalk between these agents and microRNAs (miRNAs) affects pathoetiology of several disorders. These agents can influence the redox status, release of inflammatory cytokines and mitochondrial function. Altered expression of miRNA is involved in the dysregulation of several pathophysiological conditions and signaling pathways. These molecules are also implicated in the adaption to environmental stimuli. Thus, the interactions between miRNAs and toxic materials might participate in the hazardous effects of these materials in the body. This review describes the effects of the toxic materials on miRNAs and the consequences of these interactions on the human health.

Automated summary

Toxic agents exist widely in the environment, households, and workplaces. Their contamination in food and drinking water leads to their entry into the body, where they interact with microRNAs (miRNAs), influencing the etiology of various disorders. These agents can alter redox status, release inflammatory cytokines, and affect mitochondrial function. Dysregulation of miRNA expression is implicated in the development of pathological conditions and signaling pathways, while also playing a role in environmental adaptation. Therefore, the interactions between miRNAs and toxic materials contribute to the detrimental effects on human health.