Synthetic strategies for the construction of C3-fluorinated oxindoles

C3-fluorinated oxindoles are important scaffolds known to demonstrate various biological properties. As bio-isosteres of oxindoles, these compounds have shown tremendous potential in drug research discovery programs. Besides, they also serve as starting materials for synthesizing other fluorine-containing new architectures, thus launching research for developing new methods for their synthesis. Consequently, various approaches have been developed over the years to synthesize C3-fluorinated oxindoles. This review highlights the strategies developed to date to access C3-difluoro and monofluorooxindoles via intermolecular and intramolecular approaches. The key findings of the strategies developed are discussed along with the prevailing mechanism.

Automated summary

C3-fluorinated oxindoles are important scaffolds with diverse biological activities. They hold tremendous potential in drug research and can be used as starting materials for synthesizing other fluorine-containing structures. Various approaches have been developed to synthesize C3-fluorinated oxindoles, and this review focuses on the strategies for obtaining C3-difluoro and monofluorooxindoles using intermolecular and intramolecular methods. The key findings and mechanisms of these strategies are discussed.