Journal
VIRULENCE
Volume 8, Issue 6, Pages 705-718Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2016.1261789
Keywords
blood brain barrier; CNS; fungi; infection; microglia
Categories
Funding
- NYIT College of Osteopathic Medicine intramural funds
- National Institute of General Medical Sciences of the US NIH [R15GM117501]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R15GM117501] Funding Source: NIH RePORTER
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Most fungi are capable of disseminating into the central nervous system (CNS) commonly being observed in immunocompromised hosts. Microglia play a critical role in responding to these infections regulating inflammatory processes proficient at controlling CNS colonization by these eukaryotic microorganisms. Nonetheless, it is this inflammatory state that paradoxically yields cerebral mycotic meningoencephalitis and abscess formation. As peripheral macrophages and fungi have been investigated aiding our understanding of peripheral disease, ascertaining the key interactions between fungi and microglia may uncover greater abilities to treat invasive fungal infections of the brain. Here, we present the current knowledge of microglial physiology. Due to the existing literature, we have described to greater extent the opportunistic mycotic interactions with these surveillance cells of the CNS, highlighting the need for greater efforts to study other cerebral fungal infections such as those caused by geographically restricted dimorphic and rare fungi.
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