Lipase-mediated flow synthesis of nature-inspired phenolic carbonates

A facile and convenient lipase-catalyzed flow approach for the chemoselective synthesis of tyrosol and hydroxytyrosol methyl carbonates has been developed in neat dimethylcarbonate. The products were obtained in quantitative yield with high catalyst productivity. The biocatalytic approach was then exploited for the preparation of value-added symmetrical tyrosol and hydroxytyrosol carbonates.

Automated summary

A facile and convenient lipase-catalyzed flow approach has been developed for synthesizing tyrosol and hydroxytyrosol methyl carbonates in neat dimethylcarbonate, with quantitative yield and high catalyst productivity. The biocatalytic approach can also be used for preparing value-added symmetrical tyrosol and hydroxytyrosol carbonates.