Journal
VIRULENCE
Volume 8, Issue 2, Pages 150-158Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2016.1197444
Keywords
anti-virulence therapeutics; Candida albicans; candidiasis; filamentation
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Funding
- NIH from the National Institute of Dental and Craneofacial Research [R01DE023510, R01AI119554]
- National Institute of Allergy and Infectious Diseases
- Army Research Office of the Department of Defense [W911NF-11-1-0136]
- Margaret Batts Tobin Foundation, San Antonio, TX
- UTSA RISE-PhD Trainee Program [NIH/NIGMS RISE GM60655]
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Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand the development of novel therapeutic strategies. However, there is a paucity of selective targets that can be exploited in the development of new antifungals. Contrary to conventional antibiotics that kill or curtail growth, specifically targeting virulence mechanisms represents an attractive option for antifungal drug development. In C. albicans, a growing body of research over the last few decades has provided important insights into its virulence factors and their contribution to the pathogenesis of candidiasis. Of these, filamentation is the one that has received the most attention and perhaps shows the most promise as a target for new anti-virulence strategies to combat C. albicans infections.
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