Polyvinylpyrrolidone and chitosan-coated magnetite (Fe3O4) nanoparticles for catalytic and antimicrobial activity with molecular docking analysis

This work presents the synthesis of polyvinylpyrrolidone (PVP) and chitosan (CS) coated magnetite (Fe3O4) nanoparticles (NPs) by co-precipitation technique. The objective of this research was to investigate the catalytic, antibacterial efficacy with evidential molecular docking analysis of CS/PVP- Fe3O4 and PVP/CS- Fe3O4. The coating of PVP and CS reduced the particle size of Fe3O4, providing a large surface area that increased catalytic and antibacterial potency. These binary coated magnetite NPs used as ideal catalytic agent for the reduction of rhodamine B dye as well as antibacterial agent against Escherichia coli. The findings of a molecular docking investigation were in reasonable accord with in vitro microbicidal activity and revealed that CS-Fe3O4, Fe3O4doped PVP and CS are promising inhibitors of dihydrofolate reductaseE. Coli (DHFR) and DNA gyraseE. Coli.

Automated summary

This research presents the synthesis of polyvinylpyrrolidone (PVP) and chitosan (CS) coated magnetite (Fe3O4) nanoparticles (NPs) through co-precipitation technique. The objective was to investigate the catalytic and antibacterial efficacy of CS/PVP-Fe3O4 and PVP/CS-Fe3O4 using molecular docking analysis. The findings showed that the coating of PVP and CS reduced the particle size of Fe3O4, increasing catalytic and antibacterial potency.