Journal
THERANOSTICS
Volume 6, Issue 7, Pages 986-1003Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.14860
Keywords
cancer theranostics; personalized medicine; versatile nanosystems; predetermined routing
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Funding
- National Natural Science Foundation of China [81273469, 81501582, 81573379]
- Operating Funds for Basic Sciences Research in Central Universities [2015PY011]
- Development Funds for Priority Academic Programs in Jiangsu Higher Education Institutions
- Fostering Plan of University Scientific and Technology Innovation Team of Jiangsu Qing Lan Project
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The relevance of personalized medicine, aimed at a more individualized drug therapy, has inspired research into nano-based concerted diagnosis and therapeutics (theranostics). As the intention is to kill two birds with one stone, scientists have already described the emerging concept as a treasured tailor for the future of cancer therapy, wherein the main idea is to design smart nanosystems to concurrently discharge both therapeutic and diagnostic roles. These nanosystems are expected to offer a relatively clearer view of the ingenious cellular trafficking pathway, in-situ diagnosis, and therapeutic efficacy. We herein present a detailed review of versatile nanosystems, with prominent examples of recently developed intelligent delivery strategies which have gained attention in the field of theranostics. These nanotheranostics include various mechanisms programmed in novel platforms to enable predetermined delivery of cargo to specific sites, as well as techniques to overcome the notable challenges involved in the efficacy of theranostics.
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