Journal
THERANOSTICS
Volume 6, Issue 8, Pages 1105-1118Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.14700
Keywords
Angiogenesis; hypoxia; glioma; miRNA675; optical imaging; HuR; VHL
Categories
Funding
- MIUR Ministero dell'Universita e Ricerca Scientifica [FIRB2012- RBFR12NSCF_002]
- AIRC Associazione Italiana per la Ricerca sul Cancro [12763]
- FP7 [GA305311, HEALTH-2012-INNOVATION-1]
- Doctorate School of Molecular Medicine, University of Milan, Milan, Italy
Ask authors/readers for more resources
Hypoxia is a common feature in solid tumours. In glioma, it is considered the major driving force for tumour angiogenesis and correlates with enhanced resistance to conventional therapies, increased invasiveness and a poor prognosis for patients. Here we describe, for the first time, that miR675-5p, embedded in hypoxia-induced long non-coding RNA H19, plays a mandatory role in establishing a hypoxic response and in promoting hypoxia-mediated angiogenesis. We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis. In addition, our data indicate an interaction of miR675-5p, HIF-1 alpha mRNA and the RNA Binding Protein HuR in hypoxia-induced responses. We suggest the modulation of miR675-5p as a new therapeutic option to promote or abolish hypoxia induced angiogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available