European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy

Article Immunology

Improved Organ Utilization and Better Transplant Outcomes With In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Death

Gabriel C. Oniscu et al.

Summary: The use of normothermic regional perfusion (NRP) during controlled donation after circulatory death (cDCD) is associated with increased organ recovery and improved transplant outcomes.

TRANSPLANTATION (2023)

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Article Surgery

OPTN/SRTR 2020 Annual Data Report: Pancreas

R. Kandaswamy et al.

Summary: The number of pancreas transplants and new waitlist registrations decreased in 2020. Waiting times increased for certain types of transplants, but the rates of graft failure and other long-term outcomes showed consistent improvement over the past decade.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

Normothermic ex situ pancreas perfusion for the preservation of porcine pancreas grafts

Laura Mazilescu et al.

Summary: A novel NESPP technique was developed and tested, showing that it can keep pancreas metabolically active and improve the outcomes of transplantation by allowing for assessment and repair of the organ.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

Joana Ferrer-Fabrega et al.

Summary: This study retrospectively analyzed data from 380 pancreas transplants and compared the impact of different preservation solutions on transplant outcomes. The results showed that the IGL-1 solution had better performance in perioperative complications and higher survival rates at 1, 3, and 5 years compared to other solutions. Therefore, using the IGL-1 solution for perfusion and organ preservation may be a promising choice in clinical pancreas transplantation.

TRANSPLANT INTERNATIONAL (2022)

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Article Surgery

Clinical use of donation after circulatory death pancreas for islet transplantation

Jason B. Doppenberg et al.

Summary: Despite lower islet yield, DCD islets showed similar function to DBD islets post-transplant, indicating their potential suitability for clinical islet transplantation.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Biochemistry & Molecular Biology

Ischemia-Reperfusion Injuries Assessment during Pancreas Preservation

Thomas Prudhomme et al.

Summary: In pancreas transplantation, utilizing perfusion for organ preservation has shown promising results and the development of machine perfusion techniques for whole pancreas preservation is on the rise. By evaluating various indicators during perfusion, such as edema, oxygen consumption, and cell death, researchers aim to gain a better understanding of the organ's condition.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution

Diedert L. De Paep et al.

Summary: Organs from donors after controlled circulatory death (DCD III) have lower beta cell numbers compared to those from brain death donors (DBD), but similar purity and insulin content. Shortening warm ischemia time and using specific preservation solutions can prevent the reduction in beta cell yield in DCD III organs.

PLOS ONE (2021)

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Article Surgery

Development of ex situ normothermic reperfusion as an innovative method to assess pancreases after preservation

Ann Etohan Ogbemudia et al.

Summary: The study compared static cold storage (SCS) with hypothermic machine perfusion with oxygenation (HMPO2) in pancreas preservation, showing that HMPO2 had better outcomes during normothermic reperfusion assessments.

TRANSPLANT INTERNATIONAL (2021)

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Article Health Care Sciences & Services