Journal
IEEE ACCESS
Volume 11, Issue -, Pages 79609-79623Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/ACCESS.2023.3297207
Keywords
Protein-DNA binding site prediction; neighboring residue correlations; feature processing; multi-view features combining; support vector machine
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The interaction between proteins and DNA is crucial in various biological processes. Identifying protein-DNA binding sites is important for understanding protein function and designing drugs. This study proposes a new method for predicting protein-DNA binding sites, based on neighboring residue correlations and improved feature representation. Experimental results demonstrate that this method outperforms other predictors and has significant implications in the field of biotechnology.
The interaction between proteins and DNA occurs widely during the replication and transcription of DNA and other life activities. Therefore, the identification of protein- and DNA-binding sites is important for the study of protein function and drug design. Accurate prediction of binding sites has become a challenging and significant task. Although numerous studies have been conducted, prediction is challenging. In this study, a new protein-DNA binding site prediction method was proposed. This method is based on neighboring residue correlations. It uses an improved feature representation method that weighted combines several protein characteristics after a series of processing of the features and chooses a support vector machine as the prediction engine. Experiments on benchmark datasets and independent test datasets show that the proposed method has better predictability than other protein-DNA binding site predictors. This method is complementary to the existing protein-DNA binding site predictors and will be useful in the field of biotechnology.
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