Blood lead levels of children exposed to e-waste: a systematic review and meta-analysis

Blood lead levels (BLLs) have been decreasing worldwide for decades. However, systematic reviews and quantitative syntheses of BLLs in electronic waste (e-waste)-exposed children are lacking. To summarize temporal trend of BLLs among children in e-waste-recycling areas. Fifty-one studies met the inclusion criteria and included participants from six countries. Meta-analysis was performed using the random-effects model. Results showed that among e-waste-exposed children, the total geometric mean (GM) BLL was 7.54 mu g/dL (95% CI: 6.77, 8.31). Children's BLLs displayed a decreasing temporal trend, from 11.77 mu g/dL in phase I (2004-2006) to 4.63 mu g/dL in phase V (2016-2018). Almost 95% of eligible studies found that children exposed to e-waste had significantly higher BLLs than reference groups. The difference of children's BLLs between the exposure group and the reference group was from 6.60 mu g/dL (95% CI: 6.14, 7.05) in 2004 to 1.99 mu g/dL (95% CI: 1.61, 2.36) in 2018. For subgroup analyses, except for Dhaka and Montevideo, the BLLs of children from Guiyu in the same survey year were higher than those of children from other regions. Our findings indicate that the gap between BLLs of children exposed to e-waste and those of reference group children is closing, and we appeal that the critical value for blood lead poisoning in children should be lowered in key e-waste-dismantling areas of developing countries, such as Guiyu.

Automated summary

Blood lead levels (BLLs) in e-waste-exposed children have been decreasing over time. A meta-analysis of 51 studies from six countries found that the total geometric mean BLL was 7.54 μg/dL. BLLs displayed a decreasing trend from 11.77 μg/dL in 2004-2006 to 4.63 μg/dL in 2016-2018. Nearly 95% of studies showed that e-waste-exposed children had significantly higher BLLs than the reference groups. The difference in BLLs between the exposure group and reference group decreased from 6.60 μg/dL in 2004 to 1.99 μg/dL in 2018. It was found that children from Guiyu had higher BLLs compared to other regions.