Journal
SEMINARS IN OPHTHALMOLOGY
Volume 31, Issue 1-2, Pages 59-70Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08820538.2015.1114853
Keywords
corneal neural anatomy; in vivo confocal microscopy; neuropathic pain; corneal pain; Autologous serum drops; dry eye
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Funding
- NIH [R01-EY022695]
- Research to Prevent Blindness Career Development Award
- Falk Medical Research Trust
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The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain.
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