Is BMI Associated with COVID-19 Severity? A Retrospective Observational Study

Article Surgery

Aggressive Anticoagulation May Decrease Mortality in Obese Critically III COVID-19 Patients

Panagiotis Drakos et al.

Summary: Implementing early aggressive anticoagulation in critically ill COVID-19 patients with obesity may counterbalance the negative impact of obesity on overall mortality.

OBESITY SURGERY (2022)

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Letter Anesthesiology

BMI- and age-related associations with mortality from COVID-19

T. M. Austin et al.

ANAESTHESIA (2022)

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Article Multidisciplinary Sciences

Inflammation, underweight, malignancy and a marked catabolic state as predictors for worse outcomes in COVID-19 patients with moderate-to-severe disease admitted to Internal Medicine Unit

Valeria Guglielmi et al.

PLoS One (2022)

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Article Nutrition & Dietetics

Body Mass Index Combined With Possible Sarcopenia Status Is Better Than BMI or Possible Sarcopenia Status Alone for Predicting All-Cause Mortality Among Asian Community-Dwelling Older Adults

Chalobol Chalermsri et al.

Summary: This study investigated the association between BMI combined with possible sarcopenia severity and all-cause mortality in Asian older adults. The results showed that BMI combined with possible sarcopenia severity was a better predictor of mortality risk than either parameter alone.

FRONTIERS IN NUTRITION (2022)

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Review Medicine, General & Internal

The Obesity Paradox in Chronic Heart Disease and Chronic Obstructive Pulmonary Disease

Suganya Giri Ravindran et al.

Summary: Obesity has become an epidemic, with BMI being a crucial health indicator. Like smoking, it affects multiple organ systems and is a modifiable risk factor for many diseases. However, there is a paradoxical finding that obesity positively impacts the prognosis of patients with chronic illnesses, known as the Obesity Paradox.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

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Review Nutrition & Dietetics

The obesity paradox in patients with colorectal cancer: a systematic review and meta-analysis

Yiding Li et al.

Summary: This systematic review and meta-analysis found that higher BMI is associated with reduced mortality and better outcomes in colorectal cancer patients, contradicting the established understanding of obesity as a risk factor for the disease.

NUTRITION REVIEWS (2022)

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Article Immunology

Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)

Lindsay Kim et al.

Summary: This study identified factors associated with severe outcomes among adults hospitalized with COVID-19, including age, sex, comorbidities like obesity, immunosuppression, and diabetes. Older age, male gender, and certain underlying conditions were independently linked to increased risk of ICU admission and in-hospital mortality.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Endocrinology & Metabolism

Association of body mass index (BMI) with critical COVID-19 and in-hospital mortality: A dose-response meta-analysis

Yanbin Du et al.

Summary: This study examined the association between BMI and COVID-19 severity and mortality through a meta-analysis of 16 observational studies involving 109,881 patients. The findings showed a linear dose-response relationship between BMI and critical COVID-19 and mortality, with patients with BMI > 30 kg/m(2) at higher risk. Age and obesity were also found to impact this association.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Nutrition & Dietetics

Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link?

Renata Silverio et al.

Summary: COVID-19 is a rapidly spreading disease with elderly individuals and patients with comorbidities at higher risk of severe outcomes. Nutritional status plays a crucial role in infection outcomes, with malnutrition affecting the immune system and body composition affecting disease prognosis.

ADVANCES IN NUTRITION (2021)

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Article Biotechnology & Applied Microbiology

SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department

Martin Moeckel et al.

Summary: Rapid antigen tests for SARS-CoV-2 in emergency departments can help with early identification of COVID-19 cases, but negative results should be confirmed by PCR testing and patients should remain isolated until then. Adult patients with a false negative AG test who had symptoms at least one week earlier are likely to have low viral concentrations and may no longer be infectious.

BIOMARKERS (2021)

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Article Cardiac & Cardiovascular Systems

Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19 Results From the American Heart Association COVID-19 Cardiovascular Disease Registry

Nicholas S. Hendren et al.

Summary: This study found that obese patients are more likely to be hospitalized with COVID-19, and are at higher risk of in-hospital death or mechanical ventilation, particularly if young (age <= 50 years). Additionally, obese patients are also at higher risk for venous thromboembolism and dialysis. These observations support clear public health messaging and rigorous adherence to COVID-19 prevention strategies in all obese individuals regardless of age.

CIRCULATION (2021)

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Article Public, Environmental & Occupational Health

Obesity is associated with severe COVID-19 but not death: a dose-response meta-analysis

Linyan Deng et al.

Summary: Obesity in COVID-19 patients is associated with severity but not mortality. The prevalence rate of obesity among COVID-19 patients is 30%, and obese patients are more likely to develop severe COVID-19.

EPIDEMIOLOGY AND INFECTION (2021)

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Review Virology

Obesity aggravates COVID-19: An updated systematic review and meta-analysis

Jun Yang et al.

Summary: This review evaluated the impact of obesity on COVID-19 and found that obese individuals were more likely to test positive for the virus and had higher risks of hospitalization, ICU admission, invasive mechanical ventilation, and in-hospital mortality. A higher degree of obesity also indicated higher risks, and regional differences may contribute to study heterogeneity. Further research is needed to strengthen basic and clinical therapeutic approaches.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Geriatrics & Gerontology

MALNUTRITION PROLONGS THE HOSPITALIZATION OF PATIENTS WITH COVID-19 INFECTION: A CLINICAL EPIDEMIOLOGICAL ANALYSIS

Y. Yu et al.

Summary: The study found that malnutrition may lead to prolonged hospitalization in patients with COVID-19, and extra attention and precautions should be taken during clinical treatments for these patients.

JOURNAL OF NUTRITION HEALTH & AGING (2021)

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Article Endocrinology & Metabolism

BMI as a Risk Factor for Clinical Outcomes in Patients Hospitalized with COVID-19 in New York

Tara S. Kim et al.

Summary: This study found that patients with COVID-19 who were overweight or obese had an increased risk of requiring invasive mechanical ventilation, while underweight and obese patients had an increased risk of death. Pulmonary complications seem to be significant contributors to poor outcomes in COVID-19 infection.

OBESITY (2021)

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Article Endocrinology & Metabolism

Obesity and COVID-19 in Adult Patients With Diabetes

Peihua Cao et al.

Summary: Obesity is significantly associated with a higher risk of severe pneumonia and requiring oxygen therapy in COVID-19 patients, and this risk is more pronounced in men, older adults, and those with diabetes. Overweight and obesity also increase the odds of requiring oxygen therapy, with a linear dose-response curve between BMI and severe outcomes observed in all patients.

DIABETES (2021)

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Article Endocrinology & Metabolism

Impact of obesity on COVID-19 patients

Wanqi Yu et al.

Summary: Obesity has been identified as a risk factor influencing the severity of infectious diseases, including COVID-19. This review comprehensively analyzes the impact of obesity on patients with COVID-19 and discusses prevention and management measures for this population.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

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Article Endocrinology & Metabolism

Obesity and Critical Illness in COVID-19: Respiratory Pathophysiology

Molly Wolf et al.

Summary: Recent cohort studies have identified obesity as a risk factor for poor outcomes in COVID-19. This retrospective study of critically ill patients at Massachusetts General Hospital found that obesity was not associated with significant differences in respiratory physiology, inflammatory profile, or clinical outcomes.

OBESITY (2021)

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Article Multidisciplinary Sciences

The association between body mass index and severity of Coronavirus Disease 2019 (COVID-19): A cohort study

Kulapong Jayanama et al.

Summary: This study explored the association between body mass index (BMI) levels and the severity of COVID-19. The results showed that obesity was linked to severe pneumonia and adverse outcomes, while underweight patients were more prone to acute kidney injury. Further research on body composition is needed to investigate the relationship between adiposity and COVID-19 pathogenesis.

PLOS ONE (2021)

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Review Medicine, General & Internal

Obesity and Mortality Among Patients Diagnosed With COVID-19: A Systematic Review and Meta-Analysis

Tahmina Nasrin Poly et al.

Summary: Obesity is significantly associated with an increased risk of mortality among COVID-19 patients, particularly in those aged over 65 years.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Effect of influenza vaccine on COVID-19 mortality: a retrospective study

Marcello Candelli et al.

Summary: The study aimed to investigate whether the influenza vaccine could reduce the susceptibility and severity of SARS-CoV-2 infection. It found that COVID-19-positive patients older than 65 years with flu vaccination showed a lower risk of death at 60 days. The study suggests that flu vaccination may reduce the mortality of COVID-19, with prospective studies needed for confirmation.

INTERNAL AND EMERGENCY MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Epicardial adipose tissue characteristics, obesity and clinical outcomes in COVID-19: A post-hoc analysis of a prospective cohort study

Caterina Conte et al.

Summary: The study found that the inflammation marker EAT-At in epicardial adipose tissue (EAT) is associated with critical illness in COVID-19 patients, while increasing oxygenation index (PaO2/FiO(2)) has a protective effect.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Review Nutrition & Dietetics

The Role of Nutrition in the COVID-19 Pandemic

Maria Chiara Mentella et al.

Summary: This article summarizes the complex relationship between SARS-CoV-2 infection and nutritional status, as well as the impact of malnutrition on disease severity, patients' recovery time, incidence of complications, and mortality rate. Current studies also evaluate the possibility of modulating nutrition and supplementation in combination with pharmacological treatments to prevent, support, and overcome infections in a clinical setting.

NUTRIENTS (2021)

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Article Endocrinology & Metabolism

Body composition predictors of outcome in patients with COVID-19

Katherine M. Bunnell et al.

Summary: The study aims to evaluate body composition measures obtained on opportunistic abdominal CTs as predictors of outcome in patients hospitalized with COVID-19, revealing that elevated visceral and intermuscular adipose tissue are associated with adverse outcomes.

INTERNATIONAL JOURNAL OF OBESITY (2021)

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Article Endocrinology & Metabolism

Associations between body-mass index and COVID-19 severity in 6.9 million people in England: a prospective, community-based, cohort study

Min Gao et al.

Summary: The study found that above a BMI of 23 kg/m(2), there is a linear increase in the risk of severe consequences of COVID-19 leading to hospital admission and death, and a linear increase in ICU admission risk across the entire BMI range. The impact of increasing BMI is particularly notable in individuals younger than 40 years and of Black ethnicity.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Medicine, General & Internal

Factors Associated with ICU Admission in Patients with COVID-19: The GOL2DS Score

Marcello Candelli et al.

Summary: The study identifies factors associated with ICU admission in COVID-19 patients, developing a prognostic score named GOL2DS with high accuracy in predicting ICU admission. Factors such as blood type A, PaO2/FiO2, LDH, lactate, dyspnea, and SpO2 were significantly linked to ICU admission, providing valuable insights for emergency physicians.

MEDICINA-LITHUANIA (2021)

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Article Geriatrics & Gerontology

Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19

Shu Li et al.

Summary: The severity of COVID-19 appears to be worsened by aging and obesity-related conditions, with metabolic/obesity phenotypes and vitamin D status playing significant roles. Metabolically unhealthy obesity (MUHO) and vitamin D insufficiency are associated with a significantly increased risk of COVID-19 severity, especially for adults 65 years and older. It is essential for vulnerable individuals to be aware of their conditions and avoid contact with the new coronavirus.

AGING AND DISEASE (2021)

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Review Pediatrics

A Review of Coronavirus Disease-2019 (COVID-19)

Tanu Singhal

INDIAN JOURNAL OF PEDIATRICS (2020)

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Review Infectious Diseases

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Lisheng Wang et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Nutrition & Dietetics

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections

Philip C. Calder et al.

NUTRIENTS (2020)

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Article Endocrinology & Metabolism

Prevalence of obesity among adult inpatients with COVID-19 in France

Cyrielle Caussy et al.

Lancet Diabetes & Endocrinology (2020)

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Letter Endocrinology & Metabolism

Obesity is Associated with Severe Forms of COVID-19

Cyrielle Caussy et al.

OBESITY (2020)

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Article Endocrinology & Metabolism

High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation

Arthur Simonnet et al.

OBESITY (2020)

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Editorial Material Nutrition & Dietetics

Editorial: Nutrition and COVID-19

Mario J. Soares et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Geriatrics & Gerontology

Clinical characteristics and prognostic factors in COVID-19 patients aged ≥80 years

Marcello Covino et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2020)

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Article Medicine, General & Internal

COVID-19 and chronic renal disease: clinical characteristics and prognosis

D. Yang et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2020)

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Editorial Material Nutrition & Dietetics

Reply to Overstated Claims of Efficacy and Safety. Comment On: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181

Philip C. Calder et al.

NUTRIENTS (2020)

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Article Cardiac & Cardiovascular Systems

Comorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO)

Francesca Polverino et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

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Article Nutrition & Dietetics

Prevalence and severity of malnutrition in hospitalized COVID-19 patients

Dorothee Bedock et al.

CLINICAL NUTRITION ESPEN (2020)

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Letter Gastroenterology & Hepatology

COVID-19 and intestinal inflammation: Role of fecal calprotectin

Veronica Ojetti et al.

DIGESTIVE AND LIVER DISEASE (2020)

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Article Critical Care Medicine

Predicting intensive care unit admission and death for COVID-19 patients in the emergency department using early warning scores

Marcello Covino et al.

RESUSCITATION (2020)

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Article Emergency Medicine

Preliminary Results of Initial Testing for Coronavirus (COVID-19) in the Emergency Department

Vaishal M. Tolia et al.

WESTERN JOURNAL OF EMERGENCY MEDICINE (2020)

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Editorial Material Nutrition & Dietetics

Diet and Immune Function

Caroline E. Childs et al.

NUTRIENTS (2019)

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Article Anesthesiology

Selection of Appropriate Statistical Methods for Data Analysis

Prabhaker Mishra et al.

ANNALS OF CARDIAC ANAESTHESIA (2019)

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Article Physiology

Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat

Yuebo Zhang et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Critical Care Medicine

Feasibility and Effectiveness of Prone Position in Morbidly Obese Patients With ARDS A Case-Control Clinical Study

Audrey De Jong et al.

CHEST (2013)

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Article Nutrition & Dietetics

Feeding the immune system

Philip C. Calder

PROCEEDINGS OF THE NUTRITION SOCIETY (2013)

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Article Critical Care Medicine

Obesity and ARDS

Kathryn Hibbert et al.

CHEST (2012)

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Editorial Material Biochemistry & Molecular Biology

Special Issue: Nutritional Immunology

Simin Nikbin Meydani et al.

MOLECULAR ASPECTS OF MEDICINE (2012)

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Review Biochemistry & Molecular Biology

Host nutritional status: the neglected virulence factor

MA Beck et al.

TRENDS IN MICROBIOLOGY (2004)

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Is BMI Associated with COVID-19 Severity? A Retrospective Observational Study

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