Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19

Article Medicine, General & Internal

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19

Hidde Heesakkers et al.

Summary: The study found that physical, mental, and cognitive symptoms were frequently reported among COVID-19 patients one year after ICU treatment.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Respiratory System

Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS

Nicola Latronico et al.

Summary: This study reported on the outcomes of 114 COVID-19-associated ARDS survivors evaluated at 3, 6, and 12 months after discharge from the ICU, showing persisting impairment in physical function, while activities of daily living, cognitive and mental health status, and health-related quality of life may be less impaired. The study found improvements in handgrip dynamometry and cognitive impairment over time, but 6 min walk test, severe fatigue, depression, anxiety, and post-traumatic stress disorder symptoms did not show significant improvements.

THORAX (2022)

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Article Genetics & Heredity

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Anna C. Aschenbrenner et al.

Summary: This study provides novel insights into distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. Whole blood transcriptomes are shown to be extremely informative for COVID-19 as they capture the major drivers of disease severity, granulocytes.

GENOME MEDICINE (2021)

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Article Medicine, General & Internal

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Anthony C. Gordon et al.

Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study

Lorenzo Gamberini et al.

Summary: The study found that HRQoL among COVID-19 ICU survivors improved within one year after discharge, especially in the physical dimensions, while the mental dimensions and dyspnea remained stable. Four main 15D profiles were identified, with about 47.2% of patients achieving full recovery and about 58.4% experiencing persistent dyspnea.

RESPIRATORY MEDICINE (2021)

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Article Medicine, General & Internal

Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19

Luc Morin et al.

Summary: After 4 months of hospitalization for COVID-19, a significant proportion of patients reported new symptoms and abnormalities in lung scans were common. Further research is needed to understand the long-term consequences of COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Biochemistry & Molecular Biology

Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway

Naoki Inui et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by dysregulated repair response induced by recurrent epithelial cell damage and excessive extracellular matrix accumulation. While there is currently no curative therapy for IPF, medications like pirfenidone and nintedanib have been introduced based on understanding the pathogenesis of the disease. Recent advances in understanding IPF pathogenesis have focused on epithelial-mesenchymal transition, the ubiquitin-proteasome system, and the role of endothelial cells in the disease process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Six-Month Outcomes of Post-ARDS Pulmonary Fibrosis in Patients With H1N1 Pneumonia

Jing Gao et al.

Summary: Research indicates that survivors with pulmonary fibrosis after H1N1 influenza have lower health-related quality of life scores compared to age and sex-matched controls. The 6-minute walk test and CT scores continue to be affected by the condition even after 6 months, with improvements in walking distance and imaging findings during the initial 6-month period.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Critical Care Medicine

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients

Emma J. Kooistra et al.

Summary: Cessation of dexamethasone in critically ill COVID-19 patients leads to a rebound increase in PCT and CRP levels unrelated to secondary bacterial infections. Immunomodulatory treatment with dexamethasone and tocilizumab significantly reduces the value of PCT and CRP for detecting secondary infections in COVID-19 patients.

CRITICAL CARE (2021)

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Letter Critical Care Medicine

Preclinical Pulmonary Fibrosis Circulating Protein Biomarkers

Susan K. Mathai et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

PAD4 Deficiency Improves Bleomycin-induced Neutrophil Extracellular Traps and Fibrosis in Mouse Lung

Masaki Suzuki et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Article Critical Care Medicine

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Emma J. Kooistra et al.

CRITICAL CARE (2020)

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Article Medicine, Research & Experimental

CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading

Xin Chu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Review Pharmacology & Pharmacy

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Heng Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Cell Biology

Epithelial-mesenchymal transition in tissue repair and fibrosis

Rivka C. Stone et al.

CELL AND TISSUE RESEARCH (2016)

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Article Critical Care Medicine

Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation

Jean-Marie Forel et al.

INTENSIVE CARE MEDICINE (2015)

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Review Anesthesiology

Mechanical Ventilation-associated Lung Fibrosis in Acute Respiratory Distress Syndrome A Significant Contributor to Poor Outcome

Nuria E. Cabrera-Benitez et al.

ANESTHESIOLOGY (2014)

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Review Pharmacology & Pharmacy

The role of Bcl-2 family proteins in pulmonary fibrosis

Leila Safaeian et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Review Respiratory System

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

Ellen L. Burnham et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

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Article Immunology

Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis

Thanh-Thuy T. Le et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Oncology

Neutrophil extracellular traps promote differentiation and function of fibroblasts

Akrivi Chrysanthopoulou et al.

JOURNAL OF PATHOLOGY (2014)

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Article Immunology

Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury

Vanessa J. Craig et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Medicine, General & Internal

Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study

Kazuya Ichikado et al.

BMJ OPEN (2012)

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Review Immunology

Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis

Satoshi Ueha et al.

FRONTIERS IN IMMUNOLOGY (2012)

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Article Critical Care Medicine

Quality of Life, Pulmonary Function, and Tomographic Scan Abnormalities After ARDS

Joan R. Masclans et al.

CHEST (2011)

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Article Multidisciplinary Sciences

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

Emilio Garcia-Prieto et al.

PLOS ONE (2010)

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Article Respiratory System

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice

Sergey Udalov et al.

BMC PULMONARY MEDICINE (2010)

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Review Chemistry, Medicinal

PDE4 inhibitors: a review of current developments (2005-2009)

Lluis Pages et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2009)

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Article Pathology

Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition

Marcello Guarino et al.

HUMAN PATHOLOGY (2009)

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Article Biochemistry & Molecular Biology

Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice

Fumitake Saito et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

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Article Critical Care Medicine

Methylprednisolone infusion in early severe ARDS - Results of a randomized controlled trial

G. Umberto Meduri et al.

CHEST (2007)

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Review Medicine, Research & Experimental

Epithelial-mesenchymal transition and its implications for fibrosis

R Kalluri et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

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Article Medicine, General & Internal

One-year outcomes in survivors of the acute respiratory distress syndrome

MS Herridge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19

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