Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 98, Issue 3, Pages 266-287Publisher
WILEY
DOI: 10.1002/cpt.176
Keywords
-
Categories
Funding
- National Institutes of Health from the National Institute of Environmental Health Sciences [R01 GM41935]
- National Institute of Environmental Health Sciences [R01 ES020522, P30 ES005022]
- National Center for Advancing Translational Sciences, Clinical and Translational Sciences [UL1 TR001108]
- National Institute of Child Health and Human Development [U54 HD07160]
- National Institute of General Medical Sciences [R01 GM098449]
- Netherlands Organization for Health Research and Development [90700304]
Ask authors/readers for more resources
The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
