Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 97, Issue 4, Pages 395-403Publisher
WILEY-BLACKWELL
DOI: 10.1002/cpt.64
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Funding
- Intramural NIH HHS [Z01 ES080060-09, Z01 ES080048-18] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES080048, ZIAES080060] Funding Source: NIH RePORTER
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ATP binding cassette (ABC) transporters at the blood-brain barrier function as ATP-driven xenobiotic efflux pumps and limit delivery of small molecule drugs to the brain. Here I review recent progress in understanding the regulation of the expression and transport activity of these transporters and comment on how this new information might aid in improving drug delivery to the brain.
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