Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep27351
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Funding
- Spanish Ministry of Economy and Competitiveness (MINECO) [SAF2011-25047, SAF2014-51876-R, CSD2009-0016]
- Fundacio La Marato de TV3 [674/C/2013]
- Worldwide Cancer Research Foundation [AICR 15-0404]
- MINECO [BFU2011-23745, CSD2009-00016, SEV-2015-0505]
- La Marato de TV3
- Asociacion Espanola Contra el Cancer (AECC)
- Pro CNIC Foundation
- Worldwide Cancer Research [15-0404] Funding Source: researchfish
- ICREA Funding Source: Custom
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The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic processes, including steroid metabolism. Interestingly, we identified caveolin-1 (CAV1) as an integral component of hepatic MAMs, which determine the relative cholesterol content of these ER subdomains. Finally, a detailed comparative proteomics analysis between MAMs from wild type and CAV1-deficient mice suggests that functional CAV1 contributes to the recruitment and regulation of intracellular steroid and lipoprotein metabolism-related processes accrued at MAMs. The potential impact of these novel aspects of CAV1 biology on global cell homeostasis and disease is discussed.
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