4.7 Article

A single active catalytic site is sufficient to promote transport in P-glycoprotein

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Isolation and characterization of the plasma membrane from the yeast Pichia pastoris

Karlheinz Grillitsch et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

Review Chemistry, Multidisciplinary

Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

Gergely Szakacs et al.

CHEMICAL REVIEWS (2014)

Article Multidisciplinary Sciences

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

Hassanul G. Choudhury et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Refined structures of mouse P-glycoprotein

Jingzhi Li et al.

PROTEIN SCIENCE (2014)

Article Multidisciplinary Sciences

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

Chitra A. Shintre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

Brandy Verhalen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Perspectives on the structure-function of ABC transporters: The Switch and Constant Contact Models

Anthony M. George et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2012)

Review Biochemistry & Molecular Biology

The P-glycoprotein multidrug transporter

Frances J. Sharom

ESSAYS IN BIOCHEMISTRY: ABC TRANSPORTERS (2011)

Article Biochemistry & Molecular Biology

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides IMPLICATIONS FOR CATALYSIS

Alena Siarheyeva et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations

Laszlo Csanady et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Molecular basis of multidrug transport by ABC transporters

Markus A. Seeger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)

Article Biochemistry & Molecular Biology

Alternating Access of the Putative Substrate-Binding Chamber in the ABC Transporter MsbA

Ping Zou et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Stephen G. Aller et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

Flexibility in the ABC transporter MsbA: Alternating access with a twist

Andrew Ward et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Pharmacology & Pharmacy

Cholesterol potentiates ABCG2 activity in a heterologous expression system:: Improved in vitro model to study function of human ABCG2

A. Pal et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Review Physiology

Structure and function of ABC transporters: the ATP switch provides flexible control

Kenneth J. Linton et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)

Article Pharmacology & Pharmacy

Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody

Katalin Goda et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Article Biochemistry & Molecular Biology

Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1)

Frances J. Sharom

BIOCHEMISTRY AND CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

Structure of a bacterial multidrug ABC transporter

Roger J. P. Dawson et al.

NATURE (2006)

Review Biotechnology & Applied Microbiology

Targeting multidrug resistance in cancer

G Szakács et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biochemistry & Molecular Biology

Insight in eukaryotic ABC transporter function by mutation analysis

A Frelet et al.

FEBS LETTERS (2006)

Review Biochemistry & Molecular Biology

The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research

MM Gottesman et al.

FEBS LETTERS (2006)

Article Biophysics

The remarkable transport mechanism of P-glycoprotein: A multidrug transporter

MK Al-Shawi et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2005)

Article Biochemistry & Molecular Biology

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis

G Tombline et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

How do ABC transporters drive transport?

C van der Does et al.

BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein

MK Al-Shawi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

J Chen et al.

MOLECULAR CELL (2003)

Article Biochemistry & Molecular Biology

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p

E Janas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells

K Goda et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

MF Rosenberg et al.

EMBO JOURNAL (2001)

Article Biochemistry & Molecular Biology

Transition-state formation in ATPase-negative mutants of human MDR1 protein

G Szakács et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Biochemistry & Molecular Biology

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

C Martin et al.

BIOCHEMISTRY (2000)

Article Multidisciplinary Sciences

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

ZE Sauna et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)