Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 98, Issue 2, Pages 185-195Publisher
WILEY
DOI: 10.1002/cpt.125
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Funding
- AstraZeneca
- Bristol-Myers Squibb
- Amylin Pharmaceuticals
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Adverse iatrogenic effects of especial relevance for antidiabetes medications include hypoglycemic episodes, major adverse cardiovascular (CV) events, cancer, bone fractures, pancreatic effects, genital/urinary tract infections, and weight gain. Here, recent clinical studies addressing safety profiles of antidiabetes medications are reviewed. On balance, new prospective and population-based studies continue to indicate that the benefits of improved glucose control outweigh the risks associated with antidiabetes medications in most patients with type 2 diabetes.
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