4.7 Article

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis

Steffan Vartanian et al.

MOLECULAR & CELLULAR PROTEOMICS (2016)

Article Oncology

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

Elena V. Knatko et al.

CANCER PREVENTION RESEARCH (2015)

Article Biochemistry & Molecular Biology

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

Shasha Tao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Biochemistry & Molecular Biology

Molecular basis of the Keap1-Nrf2 system

Takafumi Suzuki et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

A mechanism for the suppression of homologous recombination in G1 cells

Alexandre Orthwein et al.

NATURE (2015)

Article Cell Biology

Antioxidants can increase melanoma metastasis in mice

Kristell Le Gal et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Medicine, Research & Experimental

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

Matthias Schaefer et al.

EMBO MOLECULAR MEDICINE (2014)

Article Cell Biology

Antioxidants Accelerate Lung Cancer Progression in Mice

Volkan I. Sayin et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Biochemistry & Molecular Biology

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

Jianglin Ma et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

Glucosinolates and isothiocyanates in health and disease

Albena T. Dinkova-Kostova et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Article Multidisciplinary Sciences

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. De Nicola et al.

NATURE (2011)

Article Multidisciplinary Sciences

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Dongmei Ren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Temporal Dissection of Tumorigenesis in Primary Cancers

Steffen Durinck et al.

CANCER DISCOVERY (2011)

Article Biochemistry & Molecular Biology

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Keiko Taguchi et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

Michael McMahon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Agriculture, Dairy & Animal Science

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells

C. Boesch-Saadatmandi et al.

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2009)

Article Biochemistry & Molecular Biology

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Dung-Fang Lee et al.

MOLECULAR CELL (2009)

Review Food Science & Technology

Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

Aimee L. Eggler et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2008)

Article Multidisciplinary Sciences

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

Paul Talalay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Oncology

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts

Albena T. Dinkova-Kostova et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)

Article Biochemistry & Molecular Biology

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

DD Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

AT Dinkova-Kostova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

M Ramos-Gomez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)