Electrochemical synthesis of spirocyclic morpholines and tetrahydrofurans via an oxidative dearomatisation strategy

Simple and scalable electrochemical oxidation of the electron-rich benzene ring followed by intramolecular capture of reactive cation-radical intermediates opens access to spirocyclic morpholines and tetrahydrofurans. The obtained molecules can be readily modified to value-added building blocks.

Automated summary

The simple and scalable electrochemical oxidation of the electron-rich benzene ring, followed by intramolecular capture of reactive cation-radical intermediates, enables the synthesis of spirocyclic morpholines and tetrahydrofurans. The obtained molecules can be easily modified into valuable building blocks.