Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 21, Issue 4, Pages 838-849Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtha.2022.11.041
Keywords
alloantibodies; human platelet antigen; intracranial hemorrhage; neonatal alloimmune; thrombocytopenia; prophylaxis
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This study investigated whether a single dose of anti-HPA-1a could accelerate the elimination of HPA-1ab platelets in healthy participants. The results showed that anti-HPA-1a significantly accelerated the elimination of HPA-1ab platelets in all participants, supporting its potential use in the prevention and treatment of FNAIT in pregnant women at risk.
Background: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a rare and potentially life-threatening bleeding disorder of the fetus/newborn. Antibodies against human platelet antigen 1a (HPA-1a) are associated with the most frequent FNAIT cases. There are no approved therapies for FNAIT prevention or treatment. RLYB211 is a polyclonal HPA-1a hyperimmune IgG being developed to prevent FNAIT.Objectives: To investigate whether a single dose of anti-HPA-1a (1000 IU) could markedly accelerate the elimination of HPA-1ab platelets transfused into healthy, HPA-1a-negative participants as compared with placebo.Methods: This randomized, single-blind, placebo-controlled, single-center, phase 1/2 proof-of-concept study (EudraCT: 2019-003459-12) included HPA-1a- and HLA-A2- negative healthy men. Cohort 1 received intravenous RLYB211 or placebo 1 hour after transfusion of HPA-1ab platelets. Cohort 1B received RLYB211 or placebo, followed by platelet transfusion 1 week later. Primary endpoint was the half-life of transfused platelets in circulation after administration of RLYB211 or placebo, determined by flow cytometry. Proof of concept was & GE;90% reduction of half-life relative to placebo.Results: Twelve participants were allocated to cohort 1 or 1B and randomized to receive RLYB211 (n = 9) or placebo (n = 3). RLYB211 markedly accelerated the elim-ination of HPA-1ab platelets in all participants vs placebo. In cohort 1B, this effect was observed 7 days after RLYB211 administration. Two treatment-emergent adverse events were possibly related to treatment, both in RLYB211-treated participants. No participants developed HPA-1a antibodies at 12 or 24 weeks.Conclusion: These data support the hypothesis that anti-HPA-1a could be used as prophylaxis in women at risk of having an FNAIT-affected pregnancy.
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