Related references
Note: Only part of the references are listed.Disruption of Scube2 Impairs Endochondral Bone Formation
Yuh-Charn Lin et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2015)
Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans
Corinna Ortmann et al.
JOURNAL OF CELL SCIENCE (2015)
Notum deacylates Wnt proteins to suppress signalling activity
Satoshi Kakugawa et al.
NATURE (2015)
Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency
Helene Damhofer et al.
JOURNAL OF CELL SCIENCE (2015)
Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix
Romain Salza et al.
BIOCHEMICAL JOURNAL (2014)
Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1
Amir Al Oustah et al.
DEVELOPMENT (2014)
The NTR domain of procollagen C-proteinase enhancer-1 (PCPE-1) mediates PCPE-1 binding to syndecans-1,-2 and-4 as well as fibronectin
Tali Weiss et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells
Petra Jakobs et al.
JOURNAL OF CELL SCIENCE (2014)
Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells
Antonios D. Konitsiotis et al.
PLOS ONE (2014)
Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-Peptidase
Rocio Rebollido-Rios et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Covalent lipid modifications of proteins
Marilyn D. Resh
CURRENT BIOLOGY (2013)
Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
Aphrodite Bilioni et al.
DEVELOPMENTAL BIOLOGY (2013)
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Xinjun Zhang et al.
CELL (2012)
Scube activity is necessary for Hedgehog signal transduction in vivo
Jacque-Lynne F. A. Johnson et al.
DEVELOPMENTAL BIOLOGY (2012)
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
Adrian Creanga et al.
GENES & DEVELOPMENT (2012)
Identification of N-terminal Residues of Sonic Hedgehog Important for Palmitoylation by Hedgehog Acyltransferase
Rayshonda Y. Hardy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
An Emerging Role of Sonic Hedgehog Shedding as a Modulator of Heparan Sulfate Interactions
Stefanie Ohlig et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structural Basis of Wnt Recognition by Frizzled
Claudia Y. Janda et al.
SCIENCE (2012)
Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand
Hanna Tukachinsky et al.
CELL REPORTS (2012)
Structure and properties of the Ca2+-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions
Christine Gaboriaud et al.
BIOCHEMICAL JOURNAL (2011)
DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop
Alexandre Wojcinski et al.
DEVELOPMENTAL BIOLOGY (2011)
Sonic Hedgehog Shedding Results in Functional Activation of the Solubilized Protein
Stefanie Ohlig et al.
DEVELOPMENTAL CELL (2011)
Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration
Toshiyuki Murai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Domain and Functional Analysis of a Novel Breast Tumor Suppressor Protein, SCUBE2
Yuh-Charn Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dual Roles of the Cardin-Weintraub Motif in Multimeric Sonic Hedgehog
Pershang Farshi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum
Katie L. Ayers et al.
DEVELOPMENTAL CELL (2010)
Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans
Ming-Tzu Tsai et al.
BIOCHEMICAL JOURNAL (2009)
Paracrine Hedgehog Signaling in Cancer
Jan-Willem Theunissen et al.
CANCER RESEARCH (2009)
Heparan Sulfate and Transglutaminase Activity Are Required for the Formation of Covalently Cross-linked Hedgehog Oligomers
Tabea Dierker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells
Tabea Dierker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
NATURE (2009)
Nanoscale organization of Hedgehog is essential for long-range signaling
Neha Vyas et al.
CELL (2008)
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
John A. Buglino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The ADAM metalloproteinases
Dylan R. Edwards et al.
MOLECULAR ASPECTS OF MEDICINE (2008)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
Insights into how CUB domains can exert specific functions while sharing a common fold - Conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity
Guillaume Blanc et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development
Srinivas R. Pallerla et al.
DEVELOPMENTAL DYNAMICS (2007)
Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
Ritsuko Takada et al.
DEVELOPMENTAL CELL (2006)
Scube2 mediates Hedgehog signalling in the zebrafish embryo
Georgina E. Hollway et al.
DEVELOPMENTAL BIOLOGY (2006)
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
JA Goetz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Differential range and activity of various forms of the Hedgehog protein
RJ Dawber et al.
BMC DEVELOPMENTAL BIOLOGY (2005)
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
K Grobe et al.
DEVELOPMENT (2005)
The zebrafish-secreted matrix protein you/Scube2 is implicated in long-range regulation of Hedgehog signaling
A Kawakami et al.
CURRENT BIOLOGY (2005)
The you gene encodes an EGF-CUB protein essential for hedgehog signaling in zebrafish
IG Woods et al.
PLOS BIOLOGY (2005)
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
MH Chen et al.
GENES & DEVELOPMENT (2004)
Sorting GPI-anchored proteins
S Mayor et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
C Han et al.
DEVELOPMENT (2004)
A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones
BT Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
Y Takei et al.
DEVELOPMENT (2004)
Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways
DJ Bornemann et al.
DEVELOPMENT (2004)
The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila
SC Desbordes et al.
DEVELOPMENT (2003)
Identification of a novel family of cell-surface proteins expressed in human vascular endothelium
RB Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands
S Urban et al.
EMBO JOURNAL (2002)
Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila
JR Lee et al.
CELL (2001)
Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
Z Chamoun et al.
SCIENCE (2001)
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
JD Lee et al.
CURRENT BIOLOGY (2001)
An acylatable residue of hedgehog is differentially required in Drosophila and mouse limb development
JD Lee et al.
DEVELOPMENTAL BIOLOGY (2001)