Viscometric, ultrasonic and FTIR approach of streptomycin sulphate in the aqueous medium of K3Cit and Na3Cit at various temperatures: A Drug-Drug intermolecular interaction study

The effect of electrolyte on antibiotic drug streptomycin sulfate has been investigated at five temperatures (298.15-318.15) K and 0.1 MPa atmospheric pressure. The influence of concentrations and temperatures on the viscometric and ultrasonic properties of K3Cit and Na3Cit with water has been studied. The experimentally obtained data of ultrasonic speed (u) and viscosity (& eta;) of the solutions have been used to evaluate different parameters at the studied temperatures. A, called the Falkenhagen coefficient, and B, is the Jones-Dole coeffi-cient, transfer viscosity B-Coefficient, & UDelta;trB, at various temperatures (298.15-318.15) K were assessed by viscosity data. The ultrasonic data and the parameter for instance apparent molar isentropic compressibility,K & phi;,S, limiting apparent molar isentropic compressibility,K0 & phi;,S, and limiting apparent molar isentropic compressibility of transfer, & UDelta;trK0 & phi;,S have been analysed to study the presence of molecular interactions at different temperatures. The spectroscopic data have been used to know the existence of Hydrogen-bonding and other types of solute and solvent interactions in the solution. All these parameters have been taken to observe the different forces of attraction, association, dissociation, and structure-making/breaking properties of the drug streptomycin sulphate in the K3Cit + Water and Na3Cit + Water solutions at said temperatures.

Automated summary

The impact of electrolyte on the antibiotic drug streptomycin sulfate was studied at five different temperatures (298.15-318.15 K) and atmospheric pressure of 0.1 MPa. The influence of concentrations and temperatures on the viscometric and ultrasonic properties of K3Cit and Na3Cit with water was investigated. Experimental data of ultrasonic speed and viscosity were used to evaluate various parameters at the studied temperatures. The spectroscopic data were utilized to analyze the presence of hydrogen bonding and other types of solute-solvent interactions in the solutions.