4.4 Article

Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment

Natascha Roehlen et al.

Summary: In this study, the role of CLDN1 as a therapeutic target for hepatocellular carcinoma (HCC) was investigated using humanized monoclonal antibodies targeting non-junctional CLDN1 and various cell and animal models. The results demonstrated that targeting non-junctional CLDN1 significantly suppressed tumor growth and invasion, and affected tumor stemness, metabolism, oncogenic signaling, and the tumor immune microenvironment. These findings provide a rationale for targeting CLDN1 in the treatment of advanced HCC and lay the foundation for the development of CLDN1-specific monoclonal antibodies for clinical use.

JOURNAL OF HEPATOLOGY (2023)

Article Oncology

Claudin18.2 as a potential therapeutic target for primary ovarian mucinous carcinomas and metastatic ovarian mucinous carcinomas from upper gastrointestinal primary tumours

Fujun Wang et al.

Summary: This study analyzed the expression of claudin18.2 in primary ovarian mucinous carcinoma (POMC) and metastatic gastrointestinal mucinous carcinoma (MGMC). The results showed that claudin18.2 was highly expressed in POMCs and MGMCs derived from the upper gastrointestinal tract, suggesting it as a potential therapeutic target for these tumors.

BMC CANCER (2023)

Review Medicine, General & Internal

Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer

Sarina K. K. Mueller et al.

Summary: Surgical resection is the preferred treatment for salivary gland cancer. For inoperable and metastatic disease, various systemic therapies are available. However, there is a need for more research and molecular analysis to improve treatment outcomes.

JOURNAL OF CLINICAL MEDICINE (2022)

Review Oncology

Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma

Luana Guimaraes de Sousa et al.

Summary: In this review, the available therapies for recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) were discussed. Recent studies have revealed two molecular subtypes of ACC, which offer potential therapeutic targets. However, the current treatment for R/M ACC is not personalized and limited, and there is a need for biomarkers and new therapies development.

CURRENT ONCOLOGY REPORTS (2022)

Review Oncology

Metastatic Adenoid Cystic Carcinoma: Genomic Landscape and Emerging Treatments

Luana Guimaraes de Sousa et al.

Summary: Adenoid cystic carcinoma (ACC) is a heterogeneous cancer that commonly develops in the salivary glands. Although most patients with ACC have slow-growing disease, a subset experiences aggressive disease. There is no consensus on when to start palliative treatment for patients with indolent disease. The development of novel therapeutic strategies based on disease biology shows promise for improving survival outcomes.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

Review Oncology

Approaches to the Management of Metastatic Adenoid Cystic Carcinoma

Rex H. Lee et al.

Summary: Patients with adenoid cystic carcinoma often experience late distant metastasis, especially to the lungs, years after treatment. The optimal treatment for metastatic ACC is still unclear and the clinical benefit is modest. This article outlines management approaches for metastatic ACC, including commonly used systemic treatment regimens, local control methods, and emerging molecular targets.

CANCERS (2022)

Review Oncology

The role and mechanism of claudins in cancer

De-Wen Wang et al.

Summary: Claudins play a crucial role in constructing tight junctions, maintaining cell polarity, controlling paracellular permeability, and regulating cell proliferation and metastasis. The exact molecular mechanisms and signaling pathways underlying the importance of claudin proteins in tumorigenesis and progression have not been fully elucidated. However, they are being investigated as potential diagnostic and treatment targets for cancer.

FRONTIERS IN ONCOLOGY (2022)

Article Immunology

Preclinical characterization of a Fab-like CD3/CLDN18.2 XFab® bispecific antibody against solid tumors

Guili Xu et al.

Summary: The novel anti-CLDN18.2 x anti-CD3 bispecific antibody, ZWB67, demonstrates low affinity for anti-CD3, highly specific binding, potent cytotoxicity, and anti-tumor activity. These findings provide a basis for the future development and evaluation of this therapeutic strategy.

IMMUNOBIOLOGY (2022)

Article Pathology

Tight junction gene expression in salivary gland tumors

Maria Luiza Arrojo et al.

Summary: Salivary gland neoplasms are a heterogeneous group of tumors with different histological subtypes and distinct growth patterns, leading to varying prognoses. Specific profiles of membrane and adhesion molecules in these tumors may serve as diagnostic and prognostic markers. This study found differential expressions of genes encoding tight junction proteins in salivary gland tumors and their associations with tumor characteristics, suggesting their potential future role as diagnostic and prognostic markers.

PATHOLOGY RESEARCH AND PRACTICE (2022)

Review Oncology

Pulmonary Salivary Gland Tumor, Mucoepidermoid Carcinoma: A Literature Review

Shumin Hu et al.

Summary: Pulmonary mucoepidermoid carcinoma is the most common malignant salivary gland tumor in the lungs, requiring multiple examinations for diagnosis. Traditional treatment methods have limited efficacy, while TKI therapy and immunotherapy show potential therapeutic effects.

JOURNAL OF ONCOLOGY (2022)

Article Oncology

Claudin-2 promotes colorectal cancer growth and metastasis by suppressing NDRG1 transcription

Mingtian Wei et al.

Summary: The study demonstrates that CLDN2 is upregulated in colorectal cancer (CRC) samples and associated with poor survival. Depletion of CLDN2 significantly promotes the transcription of NDRG1, leading to termination of CRC growth and metastasis. Mechanistically, this process promotes the dissociation of the CLDN2/ZO1/ZONAB complex and the shuttle of ZONAB into the nucleus to enrich in the promoter of NDRG1.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Review Oncology

Claudins as biomarkers of differential diagnosis and prognosis of tumors

Olga P. Popova et al.

Summary: Research on the role of claudins in carcinogenesis has shown conflicting results, possibly due to variations in sampling and inconsistent methods for evaluating immune reactivity. Ambiguous expression of claudins in breast cancer, as revealed by different studies, hinders the identification of the claudin-low molecular subtype.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

Article Oncology

Targeting claudin-4 enhances chemosensitivity in breast cancer

Yi Luo et al.

CANCER SCIENCE (2020)

Review Physiology

Claudins in cancer: bench to bedside

Makoto Osanai et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

Article Endocrinology & Metabolism

Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer

Toshihiro Maeda et al.

PROSTATE (2012)

Article Biochemistry & Molecular Biology

Predicted expansion of the claudin multigene family

Katsuhiko Mineta et al.

FEBS LETTERS (2011)

Article Cell Biology

Distribution of Tight Junction Proteins in Adult Human Salivary Glands

Ola M. Maria et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2008)