Endogenous Galectin-1 Modulates Cell Biological Properties of Immortalized Retinal Pigment Epithelial Cells In Vitro

Review Biotechnology & Applied Microbiology

Targeting galectin-driven regulatory circuits in cancer and fibrosis

Karina V. Marino et al.

Summary: This article discusses the therapeutic relevance of galectins to cancer and fibrosis, and reviews the various strategies to target galectins and their progress in clinical trials.

NATURE REVIEWS DRUG DISCOVERY (2023)

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Article Multidisciplinary Sciences

Galectin-1 and-3 in high amounts inhibit angiogenic properties of human retinal microvascular endothelial cells in vitro

Anna Hillenmayer et al.

Summary: This study found that hr-GAL1 and 3 can inhibit the proliferation, migration, and apoptosis of human retinal microvascular endothelial cells, and have inhibitory effects on angiogenesis. However, hr-GAL1 and 3 do not show toxic effects on HRMEC. In addition, hr-GAL1 and 3 treatment can activate the proangiogenic Wnt/β-catenin signaling pathway.

PLOS ONE (2022)

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Article Biochemistry & Molecular Biology

Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway

Maria Consiglia Trotta et al.

Summary: Inhibition of galectin-1 can improve cell viability, reduce fibrotic protein expression, and decrease ROS content and epithelial-mesenchymal transition in high glucose conditions. This suggests that preserving retinal pigment epithelial cell integrity and functionality can be achieved by inhibiting galectin-1 in diabetic retinopathy.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Galectin-1 deletion in mice causes bone loss via impaired osteogenic differentiation potential of BMSCs

Yu Chen et al.

Summary: Bone formation depends on osteoblasts derived from BMSCs. Gal-1 plays a crucial role in immunomodulation and has been shown to promote osteogenic differentiation of BMSCs through the activation of Lrp5 expression and Wnt/beta-catenin signaling pathway. Age-related decline in Gal-1 expression in aged mice is associated with attenuated osteogenic differentiation potential of BMSCs.

FASEB JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Galectin-1 in Obesity and Type 2 Diabetes

Emanuel Fryk et al.

Summary: Galectin-1 plays a crucial role in obesity and insulin resistance, and may be associated with the development and progression of type 2 diabetes and its complications.

METABOLITES (2022)

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Article Cell Biology

Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer

Xiaolan You et al.

Aging-US (2021)

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Review Biochemistry & Molecular Biology

Tissue-specific control of galectin-1-driven circuits during inflammatory responses

Anabela M. Cutine et al.

Summary: The importance of glycan-binding proteins, especially galectins, in immune tolerance and inflammation has been well established. Galectin-1, as a prototype member of this protein family, displays mainly anti-inflammatory and immunosuppressive activities but may also have pro-inflammatory effects under certain circumstances. Further studies on the regulation and function of galectins in different tissue microenvironments could lead to tailored therapeutic strategies for pathological inflammatory conditions.

GLYCOBIOLOGY (2021)

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Review Clinical Neurology