Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep36609
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Funding
- National Natural Science Foundation of China [21472251, 41276146]
- Science & Technology Plan Project of Guangdong Province of China [2013B021100011]
- key project of Natural Science Foundation of Guangdong Province [2016A040403091]
- China Postdoctoral Science Foundation [2013M542223]
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Three novel 2,3-diaryl indone derivatives, ascomindones A-C (1-3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6-9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC50 value of 18.1 mu M.
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