Related references
Note: Only part of the references are listed.Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
Philippe Billiald et al.
BLOOD ADVANCES (2023)
Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation
Stefano Navarro et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19 A Randomized Clinical Trial
Jeffrey S. Berger et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Peter W. Horby et al.
LANCET (2022)
Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
Rainer Kaiser et al.
BLOOD (2022)
GPVI and collagen: the final word?
Alexandre Slater et al.
BLOOD (2022)
Structural insights into collagen binding by platelet receptor glycoprotein VI
Louris J. Feitsma et al.
BLOOD (2022)
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial
Charlotte A. Bradbury et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)
Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation
Natalie J. Jooss et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)
Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial
Timo Uphaus et al.
STROKE (2022)
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19
Cedric Garcia et al.
BLOOD ADVANCES (2022)
Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1
Ilaria De Simone et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Anti-GPVI Fab reveals distinct roles for GPVI signaling in the first platelet layer and subsequent layers during microfluidic clotting on collagen with or without tissue factor
Y. Zhang et al.
THROMBOSIS RESEARCH (2022)
Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI-dimer-An interaction that may modulate fibrin crosslinking
Masaaki Moroi et al.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2022)
The basement membrane protein nidogen-1 supports platelet adhesion and activation
Hari Hara Sudhan Lakshmanan et al.
PLATELETS (2021)
Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation
Gina Perrella et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)
GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region
Rui-Gang Xu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)
Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis
Soumaya Jadoui et al.
HAEMATOLOGICA (2021)
Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice
Michael Bieber et al.
EXPERIMENTAL NEUROLOGY (2021)
The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner
Henrike Hoermann et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer
Alexandre Slater et al.
BLOOD (2021)
Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial
Katharina Mayer et al.
JAMA CARDIOLOGY (2021)
Dimers of the platelet collagen receptor glycoprotein VI bind specifically to fibrin fibers during clot formation, but not to intact fibrinogen
Masaaki Moroi et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)
Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability
Emily Janus-Bell et al.
THROMBOSIS AND HAEMOSTASIS (2021)
Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner
Samantha J. Montague et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)
Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin
Muhammad Usman Ahmed et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)
Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions
Magdolna Nagy et al.
BLOOD ADVANCES (2020)
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force
Jennifer Yeung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation
Shuchi Gupta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
Alexandre Slater et al.
PLATELETS (2019)
Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab First-in-Human Healthy Volunteer Trial
Christine Voors-Pette et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)
Platelet glycoprotein VI genetic quantitative and qualitative defects
Martine Jandrot-Perrus et al.
PLATELETS (2019)
Thrombo-inflammation in acute ischaemic stroke - implications for treatment
Guido Stoll et al.
NATURE REVIEWS NEUROLOGY (2019)
Revacept, a Novel Inhibitor of Platelet Adhesion, in Patients Undergoing Elective PCI-Design and Rationale of the Randomized ISAR-PLASTER Trial
Stefanie Schuepke et al.
THROMBOSIS AND HAEMOSTASIS (2019)
Functional significance of the platelet immune receptors GPVI and CLEC-2
Julie Rayes et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Fibrinogen and fibrin: An illustrated review
Marlien Pieters et al.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2019)
Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI-Dependent Manner in an In Vitro Venous Thrombosis Model
Marcus Lehmann et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro
Ankita Misra et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Immobilized fibrinogen activates human platelets through glycoprotein VI
Pierre H. Mangin et al.
HAEMATOLOGICA (2018)
The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent
Julie Rayes et al.
HAEMATOLOGICA (2018)
Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation
I. Induruwa et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)
Immobilized fibrinogen activates human platelets through glycoprotein VI
Pierre H. Mangin et al.
HAEMATOLOGICA (2018)
The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent
Julie Rayes et al.
HAEMATOLOGICA (2018)
Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria
Theodora A. M. Claushuis et al.
BLOOD (2018)
Proteolytic processing of platelet receptors
Elizabeth E. Gardiner
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2018)
Novel Glycoprotein VI Antagonists as Antithrombotics: Synthesis, Biological Evaluation, and Molecular Modeling Studies on 2,3-Disubstituted Tetrahydropyrido(3,4-b)indoles
Shome S. Bhunia et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy
M. Y. Lee et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)
Clustering of glycoproteinVI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
N. S. Poulter et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)
Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks
Kristell Lebozec et al.
MABS (2017)
Fibrin and D-dimer bind to monomeric GPVI
Marie-Blanche Onselaer et al.
BLOOD ADVANCES (2017)
Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet
Chien-Hsin Chang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury
Christina Pachel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Liver-mediated shedding of platelet GPVI
Michael C. Berndt et al.
BLOOD (2016)
FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice
David Stegner et al.
BLOOD (2016)
Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology
Ruizhi Li et al.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2016)
Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology
Ruizhi Li et al.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2016)
Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Claire S. Whyte et al.
BLOOD (2015)
Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice
Angele Gros et al.
BLOOD (2015)
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
Elmina Mammadova-Bach et al.
BLOOD (2015)
Fibrin activates GPVI in human and mouse platelets
Osama M. Alshehri et al.
BLOOD (2015)
Visualization of fibrinogen αC regions and their arrangement during fibrin network formation by high-resolution AFM
A. D. Protopopova et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
A Computational Study of Stimulus Driven Epileptic Seizure Abatement
Peter Neal Taylor et al.
PLOS ONE (2014)
Integrin α6β1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis
Mathieu Schaff et al.
CIRCULATION (2013)
An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families
V. Matus et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)
The GPVI-Fc Fusion Protein Revacept Improves Cerebral Infarct Volume and Functional Outcome in Stroke
Silvia Goebel et al.
PLOS ONE (2013)
The GPVI - Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times
Martin Ungerer et al.
PLOS ONE (2013)
Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity
Stephane Loyau et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
Stephanie M. Jung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Extracellular Matrix Proteins in Hemostasis and Thrombosis
Wolfgang Bergmeier et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
A Humanized Glycoprotein VI (GPVI) Mouse Model to Assess the Antithrombotic Efficacies of Anti-GPVI Agents
Pierre Henri Mangin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans
Martin Ungerer et al.
CIRCULATION (2011)
Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury
Beatrice Hechler et al.
THROMBOSIS AND HAEMOSTASIS (2011)
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
Benedicte Dumont et al.
BLOOD (2009)
Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model
M. J. E. Kuijpers et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder
C. Hermans et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura
E. E. Gardiner et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
Yann Cheli et al.
BLOOD (2008)
Platelet glycoprotein VI-related clinical defects
Jane F. Arthur et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
Jane F. Arthur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Glycoprotein VI oligomerization in cell lines and platelets
O. Berlanga et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Targeting platelets in acute experimental stroke - Impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
Christoph Kleinschnitz et al.
CIRCULATION (2007)
EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism - Potential impact on atherothrombosis
Christina Grothusen et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome
C. Strassel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Bernard-Soulier syndrome (Hemorrhagiparous thrombocytic dystrophy)
Francois Lanza
ORPHANET JOURNAL OF RARE DISEASES (2006)
Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI
Katsunori Horii et al.
BLOOD (2006)
Two-phase antithrombotic protection after anti-glycoprotein VI treatment in mice
Valerie Schulte et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency
Pierre Mangin et al.
BLOOD (2006)
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo
Christophe Dubois et al.
BLOOD (2006)
Glanzmann thrombasthenia
Alan T. Nurden
ORPHANET JOURNAL OF RARE DISEASES (2006)
Laminin stimulates spreading of platelets through integrin α6β1-dependent activation of GPVI
O Inoue et al.
BLOOD (2006)
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism
Simon Lockyer et al.
THROMBOSIS RESEARCH (2006)
GPVI and α2β1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow
KL Sarratt et al.
BLOOD (2005)
Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions
JMEM Cosemans et al.
ATHEROSCLEROSIS (2005)
Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI
S Penz et al.
FASEB JOURNAL (2005)
The role of collagen in thrombosis and hemostasis
RW Farndale et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Principal role of glycoprotein VI in α2β1 and αIIbβ3 activation during collagen-induced thrombus formation
C Lecut et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented
P Mangin et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
GPVI levels in platelets: relationship to platelet function at high shear
D Best et al.
BLOOD (2003)
Platelet-collagen interaction: is GPVI the central receptor?
B Nieswandt et al.
BLOOD (2003)
Complementary roles of platelet glycoprotein VI and integrin α2β1 in collagen-induced thrombus formation in flowing whole blood ex vivo
MJE Kuijpers et al.
FASEB JOURNAL (2003)
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
S Massberg et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI)with collagen - A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen
Y Miura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation
S Moog et al.
BLOOD (2001)
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
B Nieswandt et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)