Journal
SOFT MATTER
Volume -, Issue -, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3sm00667k
Keywords
-
Ask authors/readers for more resources
This study presents a novel spiropyran-based organic-inorganic composite nanogel (NG) prepared through emulsion polymerization using upconverting nanoparticles, spiropyran, acrylic acid, and N,N′-bis(acryloyl)cystamine (BAC) compounds. The crosslinked multi-stimulus responsive nanogels can adjust the release rate by altering various parameters, making it suitable for controlling drug release in complex biological environments. The composite NGs demonstrated highly-efficient and controllable release performance for loaded drugs, providing a wide range of options for novel stimulus-responsive nanocarriers.
Herein we report a novel spiropyran (SP)-based organic-inorganic composite nanogel (NG), which was prepared using upconverting nanoparticles, spiropyran, acrylic acid and N,N & PRIME;-bis(acryloyl)cystamine (BAC) compounds under emulsion polymerisation. Compared with other polymer nanoparticles, the crosslinked multi-stimulus responsive nanogels can adjust the release rate by altering more of the parameters and this can meet the needs of a complex biological environment to control the release of drugs. Doxorubicin hydrochlorides were used as a simulated drug to test the drug loading performance and controllable drug release performance of the composite NGs. Under near-infrared light (NIR) irradiation, an acidic environment or a reducing agent, the delivery of the loaded drugs was by controlled release over 24 hours. Under mild triple stimulation (NIR light, pH 6, and 4 mM reducing agent), the loaded drug could be released more efficiently. The organic-inorganic composite NGs with highly-efficient and controllable release performance for loaded drugs provide many choices for novel stimulus responsive nanocarriers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available