In situ 3D-bioprinting MoS2 accelerated gelling hydrogel scaffold for promoting chronic diabetic wound healing

Dynamic hydrogels have been proved valuable in tissue engineering and wound healing, but improving the functionality of these hydro gels without introducing active substances for adapting to the complex chronic wound environment is still challenging. Herein, we present an MoS2 accelerated gelling hydrogel scaffold via situ three-dimensional (3D) bioprinting for promoting chronic diabetic wound healing. The simple mixing of benzaldehyde and cyanoacetate group-functionalized dextran solutions with MoS2 nano sheets would lead to the ultrafast formation of the hydrogel, which inspired us to employ the mixture as a microfluidic 3D-bioprinting ink. Besides, the printed MoS2 hydrogel scaffold exhibited antioxidant and photothermal antibacterial properties owing to the existence of MoS2 nanosheets. Thus, by directly printing the scaffold in the chronic diabetic wounds, we observed accelerated wound healing with promoted wound closure, alleviated oxidative stress, and eliminated bacterial infection. These indicated that the MoS2 accelerated gelling hydrogel scaffolds are valuable for chronic wound management.

Automated summary

We developed an MoS2 accelerated gelling hydrogel scaffold for promoting chronic diabetic wound healing through in situ three-dimensional bioprinting. The hydrogel was formed rapidly by simple mixing of benzaldehyde and cyanoacetate group-functionalized dextran solutions with MoS2 nanosheets, which were used as a microfluidic 3D-bioprinting ink. The printed MoS2 hydrogel scaffold exhibited antioxidant and photothermal antibacterial properties, leading to accelerated wound healing, wound closure, alleviated oxidative stress, and eliminated bacterial infection in chronic diabetic wounds.