4.5 Article

Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury

Related references

Note: Only part of the references are listed.
Article Neurosciences

Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity

Sarina J. Iwabuchi et al.

Summary: This study investigated the relationship between mediodorsal thalamic circuitry, negative affect, and pain severity in chronic musculoskeletal pain. The findings demonstrate altered functional connectivity of the mediodorsal thalamus with brain regions linked to mood disorders in chronic pain patients. Additionally, the burden of pain appears to enhance the affect sensitivity of mediodorsal thalamic functional connectivity.

EUROPEAN JOURNAL OF NEUROSCIENCE (2023)

Article Neurosciences

Altered Amygdala-prefrontal Connectivity in Chronic Nonspecific Low Back Pain: Resting-state fMRI and Dynamic Causal Modelling Study

Cui Ping Mao et al.

Summary: Chronic nonspecific low back pain (cNLBP) is a challenging condition to treat due to its nonspecific causes and complexity. This study investigated the connectivity between the amygdala and cortex in patients with cNLBP and found alterations in both functional and effective connectivity. These findings suggest the involvement of the amygdala in the neuropathology of cNLBP.

NEUROSCIENCE (2022)

Article Rehabilitation

Prevalence and Impact of Neuropathic and Nonneuropathic Pain in Chronic Spinal Cord Injury

Elizabeth R. Felix et al.

Summary: This study compared the prevalence, intensity ratings, and interference ratings of neuropathic pain and nociceptive pain in chronic spinal cord injury patients, finding significant differences in intensity and interference levels between neuropathic pain and non-neuropathic pain. Additionally, women and paraplegic patients were found to have a higher prevalence of neuropathic pain, providing important insights for treatment strategies.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2022)

Article Anatomy & Morphology

Premature termination of the sympathetic chain

Y. Mansour et al.

Summary: This article describes a rare variation of the sympathetic chain, where it fails to send grey rami to the L2-4 spinal nerves and terminates by joining the S1 anterior ramus. The authors provide schematic and photographic documentation of this variation and propose possible circuits to explain how visceral axons can overcome these anatomical barriers.

FOLIA MORPHOLOGICA (2022)

Article Neurosciences

Altered basal ganglia infraslow oscillation and resting functional connectivity in complex regional pain syndrome

Barbara Lee et al.

Summary: This study investigated the changes in basal ganglia loop function in CRPS patients and found that altered basal ganglia activity may be associated with motor disturbances in CRPS.

JOURNAL OF NEUROSCIENCE RESEARCH (2022)

Review Clinical Neurology

Pain and the Triple Network Model

Dirk De Ridder et al.

Summary: Acute pain is a physiological response to tissue injury, while chronic pain can lead to suffering and functional impairment. The triple network model offers a framework to understand neuropsychiatric illnesses. Personalized treatment methods should be developed for pain management.

FRONTIERS IN NEUROLOGY (2022)

Article Neurosciences

Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: A 7-Tesla functional magnetic resonance imaging study

Rebecca Robertson et al.

Summary: In the past two decades, researchers have used magnetic resonance imaging (MRI) to explore brain activation patterns during acute pain stimuli. While these studies have mainly focused on cortical regions, they have not extensively investigated discrete changes within small brain areas that play a critical role in pain responses, such as the hypothalamus, amygdala, and periaqueductal gray matter (PAG). Using ultra-high field (7-Tesla) MRI, this study examined signal changes in these specific brain regions during acute orofacial pain stimuli in awake humans. The findings revealed altered activity in subregions of the hypothalamus, amygdala, and PAG during pain stimulation, as well as sex-related differences in certain areas. This study provides insight into the activity of specific brain nuclei during acute pain stimulation in awake humans.

NEUROIMAGE (2022)

Review Neurosciences

Left and right hemispheric lateralization of the amygdala in pain

Heather N. Allen et al.

Summary: Hemispheric asymmetries within the brain have been extensively studied across species since the early 19th century. The lateralization of the amygdala, an almond-shaped brain structure located within the limbic system, is reshaping our understanding of its role in pain processing. The central nucleus of the amygdala has been shown to play a crucial role in nociceptive processing, with the right CeA having a pro-nociceptive function and the left CeA showing variable effects ranging from no modulation to anti-nociceptive function in pain models.

PROGRESS IN NEUROBIOLOGY (2021)

Article Neurosciences

Altered gray matter volume and functional connectivity in patients with herpes zoster and postherpetic neuralgia

Yu Tang et al.

Summary: Neuroimaging studies have shown abnormalities in brain structure and function in patients with postherpetic neuralgia (PHN) and herpes zoster (HZ). This study found significant differences in gray matter volume and functional connectivity in the transition from HZ to PHN, particularly in the right putamen. These changes are closely associated with chronic pain and may provide new insights into the pathophysiology of PHN.

BRAIN RESEARCH (2021)

Article Multidisciplinary Sciences

Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia

Nasim Maleki et al.

Summary: This study utilized functional neuroimaging to investigate the differences in brain activation of patients with episodic migraine based on their allodynic status. Differences were found in brain activity in various regions between the ictal and interictal visits, with notable differences along the trigeminal pathway in patients with generalized allodynia. These findings indicate hyper-responsiveness in certain brain regions in migraine patients experiencing allodynia during attacks.

PLOS ONE (2021)

Article Neurosciences

Supraspinal nociceptive networks in neuropathic pain after spinal cord injury

Vincent Huynh et al.

Summary: Neuropathic pain following spinal cord injury involves plastic changes along the whole neuroaxis, with current neuroimaging studies showing a relationship between pain intensity and grey matter volume and connectivity changes. The underlying neural processes related to pain extent in neuropathic pain are still unknown.

HUMAN BRAIN MAPPING (2021)

Article Clinical Neurology

Tapentadol and oxycodone affect resting-state functional brain connectivity: A randomized, placebo-controlled trial

Suganthiya S. Croosu et al.

Summary: This study investigated the changes in functional brain connectivity induced by treatment with oxycodone and tapentadol in healthy volunteers compared to placebo. The results showed different patterns of functional connectivity between thalamus and other brain regions for the two treatments, supporting that they exert different mechanisms of action in pain processing. Further studies with larger sample sizes are needed to validate these findings.

JOURNAL OF NEUROIMAGING (2021)

Article Clinical Neurology

Microstructural plasticity in nociceptive pathways after spinal cord injury

Sreenath P. Kyathanahally et al.

Summary: This study tracked the structural changes in nociceptive pathways after spinal cord injury and their relationship to neuropathic pain intensity. Results showed differences in structural parameters in specific brain and spinal cord regions of individuals with neuropathic pain, indicating a critical role of microstructural changes in neuropathic pain maintenance.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Article Biology

Neural dynamics between anterior insular cortex and right supramarginal gyrus dissociate genuine affect sharing from perceptual saliency of pretended pain

Yili Zhao et al.

Summary: This study investigated how empathy for others' pain is influenced by genuine vs. pretended pain expressions. Results showed stronger activations in regions associated with affect sharing and self-other distinction when participants viewed genuine pain facial expressions. Neural dynamics revealed reduced inhibitory effect between aIns and rSMG for genuine pain, which was linked to pain ratings and empathic traits. These findings suggest that neural responses differ based on the authenticity of the perceived pain, impacting empathic responses and social support.

ELIFE (2021)

Article Clinical Neurology

Functional Hyperconnectivity and Task-Based Activity Changes Associated With Neuropathic Pain After Spinal Cord Injury: A Pilot Study

Shana R. Black et al.

Summary: Neuropathic pain is a chronic pain condition affecting a large population of spinal cord injury patients, with poorly understood neurophysiological mechanisms. Recent neuroimaging studies suggest differential patterns of functional activity in patients with neuropathic pain. Analysis using functional magnetic resonance imaging (fMRI) and high-resolution resting state fMRI revealed significant differences in functional activation and connectivity in the brains of neuropathic pain patients compared to non-painful patients within the spinal cord injury cohort.

FRONTIERS IN NEUROLOGY (2021)

Article Neurosciences

The neural networks underlying reappraisal of empathy for pain

Navot Naor et al.

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE (2020)

Article Clinical Neurology

Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life

Farah Cherif et al.

PAIN RESEARCH & MANAGEMENT (2020)

Editorial Material Clinical Neurology

What is the role of the cingulate cortex in pain?

Eduardo E. Benarroch

NEUROLOGY (2020)

Article Multidisciplinary Sciences

Parabrachial nucleus circuit governs neuropathic pain-like behavior

Li Sun et al.

NATURE COMMUNICATIONS (2020)

Review Anesthesiology

Chronic pain: a review of its epidemiology and associated factors in population-based studies

Sarah E. E. Mills et al.

BRITISH JOURNAL OF ANAESTHESIA (2019)

Article Neurosciences

Shifting brain circuits in pain chronicity

Andrew M. Youssef et al.

HUMAN BRAIN MAPPING (2019)

Review Anesthesiology

A Comprehensive Algorithm for Management of Neuropathic Pain

Daniel Bates et al.

PAIN MEDICINE (2019)

Review Medicine, General & Internal

Current understanding of the mixed pain concept: a brief narrative review

Rainer Freynhagen et al.

CURRENT MEDICAL RESEARCH AND OPINION (2019)

Article Neurosciences

Dysregulation of Pain- and Emotion-Related Networks in Trigeminal Neuralgia

Yanyang Zhang et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2018)

Review Behavioral Sciences

Brain changes after spinal cord injury, a quantitative meta-analysis and review

Linda Solstrand Dahlberg et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Article Clinical Neurology

Corticolimbic anatomical characteristics predetermine risk for chronic pain

Etienne Vachon-Presseau et al.

BRAIN (2016)

Article Multidisciplinary Sciences

Association of pain and CNS structural changes after spinal cord injury

Catherine R. Jutzeler et al.

SCIENTIFIC REPORTS (2016)

Editorial Material Neuroimaging

Minimum statistical standards for submissions to Neuroimage: Clinical

J. P. Roiser et al.

NEUROIMAGE-CLINICAL (2016)

Article Clinical Neurology

Phenotypes and Predictors of Pain Following Traumatic Spinal Cord Injury: A Prospective Study

Nanna Brix Finnerup et al.

JOURNAL OF PAIN (2014)

Article Clinical Neurology

Sex Differences in the Neural Representation of Pain Unpleasantness

Lydia Girard-Tremblay et al.

JOURNAL OF PAIN (2014)

Article Clinical Neurology

Opioid modulation of resting-state anterior cingulate cortex functional connectivity

Stephanie M. Gorka et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

A study on small-world brain functional networks altered by postherpetic neuralgia

Yue Zhang et al.

MAGNETIC RESONANCE IMAGING (2014)

Article Clinical Neurology

The International Spinal Cord Injury Pain Basic Data Set ( version 2.0)

E. Widerstroem-Noga et al.

SPINAL CORD (2014)

Article Clinical Neurology

Altered Resting-State Functional Connectivity in Complex Regional Pain Syndrome

Anne Bolwerk et al.

JOURNAL OF PAIN (2013)

Review Clinical Neurology

The Angular Gyrus: Multiple Functions and Multiple Subdivisions

Mohamed L. Seghier

NEUROSCIENTIST (2013)

Review Behavioral Sciences

The role of the parahippocampal cortex in cognition

Elissa M. Aminoff et al.

TRENDS IN COGNITIVE SCIENCES (2013)

Article Neurosciences

Separating brain processing of pain fromthat of stimulus intensity

Bruno G. Oertel et al.

HUMAN BRAIN MAPPING (2012)

Review Neurosciences

Neuroimaging of the periaqueductal gray: State of the field

Clas Linnman et al.

NEUROIMAGE (2012)

Article Neurosciences

Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks

Susan Whitfield-Gabrieli et al.

BRAIN CONNECTIVITY (2012)

Article Neurosciences

First pain in humans: convergent and specific forebrain responses

Dagfinn A. Matre et al.

MOLECULAR PAIN (2010)

Article Psychology, Experimental

Cortical Thickness and Pain Sensitivity in Zen Meditators

Joshua A. Grant et al.

EMOTION (2010)

Article Neurosciences

Somatotopic Organization of Gentle Touch Processing in the Posterior Insular Cortex

Malin Bjornsdotter et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Anesthesiology

Human brain mechanisms of pain perception and regulation in health and disease

AV Apkarian et al.

EUROPEAN JOURNAL OF PAIN (2005)