4.5 Article

Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson's disease and essential tremor

Related references

Note: Only part of the references are listed.
Article Neurosciences

Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach

Mojtaba Jokar et al.

Summary: This study developed a comprehensive imaging biomarker for diagnosing Parkinson's disease by using a template-based, automatic segmentation method to detect the features of neuromelanin and iron in the substantia nigra. The combination of the N1 sign with other quantitative measures significantly improved the accuracy of Parkinson's disease diagnosis.

NEUROIMAGE (2023)

Letter Radiology, Nuclear Medicine & Medical Imaging

Neuromelanin? MRI of Noradrenergic and Dopaminergic Neurons

Takashi Watanabe

JOURNAL OF MAGNETIC RESONANCE IMAGING (2023)

Article Neurosciences

Automatic detection of neuromelanin and iron in the midbrain nuclei using a magnetic resonance imaging-based brain template

Zhijia Jin et al.

Summary: Parkinson's disease is a chronic progressive neurodegenerative disorder characterized by the loss of neuromelanin in the substantia nigra and increased iron deposition. This study developed an automatic segmentation method for the deep gray matter nuclei in the midbrain based on iron and neuromelanin contrast using MRI. The results showed strong agreement with manually drawn structures, demonstrating the potential of accurately measuring tissue properties of the midbrain nuclei using this approach.

HUMAN BRAIN MAPPING (2022)

Article Clinical Neurology

Tremor associated with similar structural networks in Parkinson's disease and essential tremor

Pavel Filip et al.

Summary: The study found higher structural connectivity in the cerebello-thalamo-cortical network in ET patients compared to healthy controls, while tremor-dominant PD patients and PD patients without tremor showed similar results, with shared nodes with ET's tremor network. This suggests that the cerebello-thalamo-cortical network may be the dominant driver of tremor in both PD and ET, potentially explaining the different clinical features of tremor in these two disorders.

PARKINSONISM & RELATED DISORDERS (2022)

Article Neurosciences

Preserved noradrenergic function in Parkinson's disease patients with rest tremor

Martin B. Kinnerup et al.

Summary: Parkinson's disease patients with rest tremor showed relatively preserved noradrenaline terminal function in the locus coeruleus and thalamus, compared to those without rest tremor. The greater loss of noradrenergic transporters in patients without rest tremor in these regions could potentially contribute to their tremor negative phenotype.

NEUROBIOLOGY OF DISEASE (2021)

Article Clinical Neurology

Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson's disease

Christopher E. J. Doppler et al.

Summary: This study investigated neurodegeneration in the locus coeruleus of Parkinson's disease patients, finding reduced MRI contrast and volume in the locus coeruleus, as well as lower noradrenaline transporter density, with a negative correlation between the two. These results suggest distinct patterns of degeneration in different regions of the locus coeruleus in Parkinson's disease.

BRAIN (2021)

Article Clinical Neurology

Association of Locus Coeruleus and Substantia Nigra Pathology With Cognitive and Motor Functions in Patients With Parkinson Disease

Jannik Prasuhn et al.

Summary: Neuromelanin imaging of the substantia nigra and locus coeruleus can effectively reflect neurodegeneration in Parkinson's disease, with substantia nigra pathology correlating with motor dysfunction and locus coeruleus pathology being associated with cognitive impairment. Neuromelanin-weighted imaging of the locus coeruleus may serve as a marker for cognitive dysfunction in Parkinson's disease.

NEUROLOGY (2021)

Article Clinical Neurology

Neuromelanin-sensitive magnetic resonance imaging in disease differentiation for parkinsonism or neurodegenerative disease affecting the basal ganglia

Keita Matsuura et al.

Summary: Using neuromelanin-sensitive magnetic resonance imaging (NMI) can effectively differentiate neurodegenerative diseases like Parkinson's disease (PD) and progressive supranuclear palsy (PSP). The contrast ratio of the locus coeruleus (LC-CR) serves as a promising biomarker for distinguishing PD from PSP, with an area under the receiver-operating characteristic curve of 0.85.

PARKINSONISM & RELATED DISORDERS (2021)

Article Clinical Neurology

Association of Locus Coeruleus and Substantia Nigra Pathology With Cognitive and Motor Functions in Patients With Parkinson Disease

Jannik Prasuhn et al.

Summary: This study investigated the contribution of substantia nigra (SN) and locus coeruleus (LC) pathology to clinical signs and symptoms in Parkinson disease (PD) using neuromelanin-weighted imaging. The results showed that SN pathology was associated with motor dysfunction, while LC pathology correlated with cognitive impairment. The findings suggest that neuromelanin-weighted imaging of LC could serve as an imaging marker of cognitive dysfunction in PD.

NEUROLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Substantia Nigra Volumetry with 3-T MRI n De Novo and Advanced Parkinson Disease

Paolo Vitali et al.

RADIOLOGY (2020)

Article Clinical Neurology

Differential diagnosis of tremor syndromes using MRI relaxometry

Pavel Filip et al.

PARKINSONISM & RELATED DISORDERS (2020)

Article Anatomy & Morphology

Unraveling the contributions to the neuromelanin-MRI contrast

Nikos Priovoulos et al.

BRAIN STRUCTURE & FUNCTION (2020)

Article Anatomy & Morphology

Magnetic resonance imaging of noradrenergic neurons

Takashi Watanabe et al.

BRAIN STRUCTURE & FUNCTION (2019)

Article Clinical Neurology

Multimodal dopaminergic and free-water imaging in Parkinson's disease

Jing Yang et al.

PARKINSONISM & RELATED DISORDERS (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Contrast Mechanisms Associated With Neuromelanin-MRI

Paula Trujillo et al.

MAGNETIC RESONANCE IN MEDICINE (2017)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients

S. Reimao et al.

EUROPEAN JOURNAL OF NEUROLOGY (2015)

Article Clinical Neurology

Neuromelanin Magnetic Resonance Imaging in Parkinson's Disease and Multiple System Atrophy

Keita Matsuura et al.

EUROPEAN NEUROLOGY (2013)

Article Clinical Neurology

Brain Biochemistry in Autopsied Patients with Essential Tremor

Holly A. Shill et al.

MOVEMENT DISORDERS (2012)

Editorial Material Clinical Neurology

Locus Coeruleus Dysfunction: A Feature of Essential or Senile Tremor?

Guenther Deuschl

MOVEMENT DISORDERS (2012)

Article Clinical Neurology

Handedness and motor symptom asymmetry in Parkinson's disease

Matthew J. Barrett et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)

Article Clinical Neurology

Pathology in essential tremor

Holly A. Shill et al.

PARKINSONISM & RELATED DISORDERS (2011)

Article Clinical Neurology

Akineto-rigid vs. tremor syndromes in Parkinsonism

Adam Zaidel et al.

CURRENT OPINION IN NEUROLOGY (2009)

Article Neurosciences

In vivo mapping of the human locus coeruleus

Noam I. Keren et al.

NEUROIMAGE (2009)

Article Multidisciplinary Sciences

Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice

K. S. Rommelfanger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)