Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep26326
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Funding
- National Natural Science Foundation of China [31230047, 81571386, 81471508, 31429004]
- Interdisciplinary project of Peking University Third Hospital
- Chinese Academy of Sciences
- Research fund of National Health and Family Planning Commission of China [201402004]
- Mega-projects of Science Research for the 12th Five-year Plan [2012ba132b05]
- Key Research Program of the Chinese Academy of Sciences [KJZD-EW-TZ-L03-2]
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Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.
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