The mitochondria in schizophrenia with 22q11.2 deletion syndrome: From pathogenesis to therapeutic promise of targeted natural drugs

Schizophrenia is a complex multi-factor neurological disorder that caused an array of severe indelible conse-quences to the individuals and society. Additionally, anti-schizophrenic drugs are unsuitable for treating negative symptoms and have more significant side effects and drug resistance. For better treatment and prevention, we consider exploring the pathogenesis of schizophrenia from other perspectives. A growing body of evidence of 22q11.2 deletion syndrome (22q11DS) suggested that the occurrence and progression of schizophrenia are related to mitochondrial dysfunction. So combing through the literature of 22q11DS published from 2000 to 2023, this paper reviews the mechanism of schizophrenia based on mitochondrial dysfunction, and it focuses on the natural drugs targeting mitochondria to enhance mitochondrial function, which are potential to improve the current treatment of schizophrenia.

Automated summary

Schizophrenia is a complex neurological disorder with severe consequences for individuals and society. Traditional drugs have limitations in treating negative symptoms and often have side effects and drug resistance. This paper reviews the mechanism of schizophrenia based on mitochondrial dysfunction, focusing on natural drugs that enhance mitochondrial function as potential improvements to current treatment.