Increased RSV-A Bronchiolitis Severity in RSV-Infected Children Admitted to a Reference Center in Catalonia (Spain) Between 2014 and 2018

Article Pediatrics

Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol

Jorgina Vila et al.

Summary: The study found a significant reduction in the use of treatments and diagnostic tests after implementing the 2015 HBP, without significant changes in clinical outcomes. Efforts are still needed to further reduce the use of specific medications and tests.

PEDIATRIC DRUGS (2022)

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Article Immunology

Viral Interference between Respiratory Viruses

Jocelyne Piret et al.

Summary: Multiple respiratory viruses can infect the respiratory tract simultaneously or sequentially and interact with each other. The interaction between a first virus and a second virus may enhance or reduce infection and replication, resulting in positive or negative interactions. The interferon response is likely a mechanism that provides temporary nonspecific immunity to the host. Studying the interactions among respiratory viruses is important for understanding their transmission and control.

EMERGING INFECTIOUS DISEASES (2022)

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Article Microbiology

Human Respiratory Syncytial Virus Subgroup A and B Infections in Nasal, Bronchial, Small-Airway, and Organoid-Derived Respiratory Cultures

L. C. Rijsbergen et al.

Summary: This study compared the replicative fitness and cytokine responses of HRSV-A and HRSV-B strains in disease-relevant cell culture models. The results showed that subgroup A viruses disseminated and replicated faster than subgroup B viruses, suggesting that subgroup A viruses may cause more severe disease in infants. Additionally, airway organoids cultured at air-liquid interface were demonstrated to be a valuable model for studying HRSV infection ex vivo and for further research into factors influencing HRSV disease severity.

MSPHERE (2021)

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Article Immunology