Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 11, Issue 14, Pages 3195-3211Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb02094g
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In this study, a hierarchically porous nano-object (USPIO@MIL) was designed through a one-pot, cost-effective and environmentally friendly protocol, combining a benchmark nanoMOF (MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (maghemite). The USPIO@MIL nano-object exhibited valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity, stimuli-responsive drug release, and superparamagnetic properties. It also showed high anti-inflammatory and anti-tumoral activities when loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate), and demonstrated excellent relaxometric properties as an efficient contrast agent for magnetic resonance imaging.
Among a plethora of drug nanocarriers, biocompatible nanoscale metal-organic frameworks (nanoMOFs) with a large surface area and an amphiphilic internal microenvironment have emerged as promising drug delivery platforms, mainly for cancer therapy. However, their application in biomedicine still suffers from shortcomings such as a limited chemical and/or colloidal stability and/or toxicity. Here, we report the design of a hierarchically porous nano-object (denoted as USPIO@MIL) combining a benchmark nanoMOF (that is, MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (that is, maghemite) that is synthesized through a one-pot, cost-effective and environmentally friendly protocol. The synergistic coupling of the physico-chemical and functional properties of both nanoparticles confers to these nano-objects valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity as well as stimuli-responsive drug release and superparamagnetic properties. This bimodal MIL-100(Fe)/maghemite nanocarrier once loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate) shows high anti-inflammatory and anti-tumoral activities. In addition, the USPIO@MIL nano-object exhibits excellent relaxometric properties and its applicability as an efficient contrast agent for magnetic resonance imaging is herein demonstrated. This highlights the high potential of the maghemite@MOF composite integrating the functions of imaging and therapy as a theranostic anti-inflammatory formulation.
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