Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 127, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2023.110784
Keywords
Dopamine; Long term potentiation; Prefrontal cortex; Cognition; Methamphetamine
Ask authors/readers for more resources
D1-like receptors are metabotropic and activated by phasic dopamine. A proposed model suggests that the amount of contact between D1-like receptors and dopamine determines long term potentiation in the prefrontal cortex. This model also explains the detrimental cognitive effects of stimulants on regular substance consumers.
D1-like receptors have two important qualities, they are all metabotropic and they activate with phasic dopamine. After analyzing the molecular implications of each of these qualities separately and then combining them for the specific case of the prefrontal cortex, we propose a model that explains why long term potentiation in this cortical area depends on the amount of contact between D1-like receptors and dopamine. This simple model also explains why in order to promote long term potentiation, dopamine transporters should be scarce in the prefrontal cortex. Additionally, it explains why stimulants like methamphetamine could have such detrimental cognitive effects on regular substance consumers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available