4.2 Article

Extracellular matrix turnover biomarkers reflect pharmacodynamic effects and treatment response of adalimumab in patients with axial spondyloarthritis-results from two randomized controlled trials

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

A Specific Calprotectin Neo-epitope [CPa9-HNE] in Serum from Inflammatory Bowel Disease Patients Is Associated with Neutrophil Activity and Endoscopic Severity

Joachim Hog Mortensen et al.

Summary: The study developed a novel serum calprotectin enzyme-linked immunosorbent assay for monitoring disease activity in inflammatory bowel disease patients. This method showed strong correlations with endoscopic scores and disease severity.

JOURNAL OF CROHNS & COLITIS (2022)

Article Rheumatology

Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase 3 Clinical Trial (DISCOVER-2)

Georg Schett et al.

Summary: The study found that serum collagen biomarkers are elevated in patients with PsA compared to healthy controls, and treatment with guselkumab decreases the levels of these biomarkers. Additionally, C1M levels are associated with improvement in joint symptoms.

RHEUMATOLOGY AND THERAPY (2022)

Review Biochemistry & Molecular Biology

Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

Alexandra-Diana Diaconu et al.

Summary: Axial spondyloarthritis is a chronic inflammatory disease that has a significant impact on quality of life and is associated with comorbidities such as cardiovascular diseases, mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are crucial in improving the patient's prognosis. However, there is currently a lack of biomarkers that can be used in clinical practice. The existing studies provide valuable data for better disease management.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Rheumatology

Levels of extracellular matrix metabolites are associated with changes in Ankylosing Spondylitis Disease Activity Score and MRI inflammation scores in patients with axial spondyloarthritis during TNF inhibitor therapy

Signe Holm Nielsen et al.

Summary: This study investigated the association of extracellular matrix (ECM) metabolites with treatment response in axSpA patients receiving TNF-alpha inhibitory therapy. The results showed that certain ECM metabolites were associated with ASDAS response, MRI inflammation, and clinical treatment response.

ARTHRITIS RESEARCH & THERAPY (2022)

Review Rheumatology

A glance into the future of diagnosis and treatment of spondyloarthritis

Victoria Navarro-Compan et al.

Summary: The field of spondyloarthritis has experienced significant developments in the past two decades, but there are still unmet needs. The future holds promise for advancements in the diagnosis and treatment of the disease, including increased awareness through online and social media tools, the availability of more specific diagnostic tests, novel treatment targets, and the use of artificial intelligence for data analysis.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2022)

Article Rheumatology

Extracellular matrix protein turnover markers are associated with axial spondyloarthritis-a comparison with postpartum women and other non-axial spondyloarthritis controls with or without back pain

Helena Port et al.

Summary: This study investigated circulating biomarkers of extracellular matrix (ECM) remodeling and inflammation as potential markers to identify patients with axial spondyloarthritis (axSpA). The results showed that axSpA patients had altered turnover of type I, IV, and VI collagens compared to non-axSpA control groups. The biomarker PRO-C4 was found to be the best indicator for differentiating axSpA patients from non-axSpA subjects.

ARTHRITIS RESEARCH & THERAPY (2022)

Review Rheumatology

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

Daniele Mauro et al.

Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease with features of both autoimmune and autoinflammatory processes. While the innate immune system plays a dominant role in AS, factors such as the intestine and biomechanical elements may also contribute to the disease's pathogenesis. Studies suggest a combination of autoinflammation and autoimmunity in AS, with evidence supporting both hypotheses.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Multidisciplinary Sciences

A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis

Dovile Sinkeviciute et al.

SCIENTIFIC REPORTS (2020)

Article Rheumatology

Treatment strategies in axial spondyloarthritis: what, when and how?

George E. Fragoulis et al.

RHEUMATOLOGY (2020)

Review Multidisciplinary Sciences

Targeting tumor necrosis factor receptors in ankylosing spondylitis

Michal Lata et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Article Rheumatology

The Pathogenesis of Ankylosing Spondylitis: an Update

Susanne Juhl Pedersen et al.

CURRENT RHEUMATOLOGY REPORTS (2019)

Article Endocrinology & Metabolism

A marker of type VI collagen formation (PRO-C6) is associated with higher arterial stiffness in type 1 diabetes

Marie Frimodt-Moller et al.

ACTA DIABETOLOGICA (2019)

Article Biochemistry & Molecular Biology

A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation

Yunyun Luo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Medicine, General & Internal

Axial spondyloarthritis

Joachim Sieper et al.

LANCET (2017)

Article Rheumatology

Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis

Natasja Saethr Gudmann et al.

ARTHRITIS RESEARCH & THERAPY (2016)