Base-promoted one-pot three-component desulphurization cross-coupling access to 4-cyanoimidazole

A novel, straightforward, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy is reported for the synthesis of 4-cyanoimidazole derivatives. Over 35 examples are provided and achieved yields exceeding 85%. Notably, the majority of these readily available compounds can be isolated through simple filtration, thereby circumventing the need for laborious column chromatography. Besides, the present protocol can be scaled up to 10 mmol with a yield of 87%, demonstrating promising potential for industrial applications. Herein, we present a pioneering, facile, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy for the synthesis of 4-cyanoimidazole derivatives.

Automated summary

A novel, straightforward, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy for the synthesis of 4-cyanoimidazole derivatives is reported herein. The strategy achieved yields exceeding 85% in over 35 examples, with the majority of the compounds being readily isolated through simple filtration, avoiding laborious column chromatography. The protocol demonstrated promising potential for industrial applications, showing a yield of 87% when scaled up to 10 mmol.