Chemically reduced graphene oxide sheets for voltammetric determination of ciprofloxacin in biological fluids and pharmaceutical formulations

In the present work, graphene oxide (GO) reduced by ethyl acetate was used as modifier of graphite electrode (rGO-CPE) for the determination of Ciprofloxacin (Cipro). The rGO-CPE was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The electrochemical behavior of Cipro was performed in phosphate buffer solution (0.1 mol/L PBS, pH 7). Under the optimized parameters, the obtained detection limit is (DL=2.18 x 10-9 mol/L). The developed sensor showed excellent repeatability, estimated in terms of relative standard deviation to be (RSD = 2.917%), for n = 8, and has been successfully applied for Cipro recognition in urine and pharmaceutical formulations samples.

Automated summary

In this study, graphene oxide (GO) reduced by ethyl acetate was used to modify the graphite electrode (rGO-CPE) for the detection of Ciprofloxacin (Cipro). The rGO-CPE was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The electrochemical behavior of Cipro was studied in a phosphate buffer solution (0.1 mol/L PBS, pH 7). Under optimized parameters, the detection limit obtained was DL=2.18 x 10-9 mol/L. The developed sensor exhibited excellent repeatability with a relative standard deviation (RSD) of 2.917% (n=8) and has been successfully applied for Cipro recognition in urine and pharmaceutical formulation samples.