Continuous-flow reductive N-methylation with highly active heterogeneous Pd catalysts and sequential-flow synthesis of N-monomethyl amines

We describe continuous-flow N-methylation with formaldehyde and H(2 )using heterogeneous Pd catalysts as a green synthetic method to access N-methyl amines. The catalyst exhibited excel-lent activity for aliphatic and aromatic amines. The developed method was also applied to sequential hydrogenation reactions to access challenging N-monomethyl amines.

Automated summary

This study presents a green synthetic method using heterogeneous Pd catalysts for continuous-flow N-methylation with formaldehyde and H(2) to obtain N-methyl amines. The catalyst exhibited excellent activity for aliphatic and aromatic amines. The developed method was also applied to sequential hydrogenation reactions to access challenging N-monomethyl amines.