Journal
INFLAMMOPHARMACOLOGY
Volume -, Issue -, Pages -Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-023-01312
Keywords
Medications; Therapeutics; Musculoskeletal pain
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Non-medicinal therapies using water, salts, exercise, massage, supportive devices, and electricity have been used for centuries to benefit individuals with musculoskeletal disorders. The development of various medications, including morphine-derived products, acetyl salicylic acid, nonsteroidal anti-inflammatory agents, paracetamol, corticosteroids, and biologics, has significantly advanced joint pain management. The main objectives of managing musculoskeletal pain are to reduce or eliminate joint pain, improve joint function and mobility, enhance muscle strength, and prevent damage to joint cartilage and supporting structures.
Non-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centuries and continue to be of benefit for some people with musculoskeletal disorders. Historical texts refer to the two electuaries mithridatium and theriaca as early therapeutic attempts of man to provide relief of musculoskeletal symptoms and attempt disease cures. For over 200 years, morphine-derived products have been used for musculoskeletal pain. The development of acetyl salicylic acid was a major breakthrough in joint pain management. This was followed by the introduction of nonsteroidal anti-inflammatory agents, paracetamol, and the use of corticosteroids. The gold-based compounds were the initial disease-modifying drugs and have been followed by the highly successful biologics agents. The basic objectives of musculoskeletal pain management include: reduction or elimination of joint pain; improvement or restoration of joint function and mobility; improvement of muscle strength to protect cartilage, ligaments, and joint capsule; prevention and reduction of damage to joint cartilage and supporting structures.
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