4.6 Article

Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues

Journal

RSC ADVANCES
Volume 6, Issue 116, Pages 115298-115302

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra21260c

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Funding

  1. National Natural Science Foundation of China [21305036, 21507135]
  2. Hunan Provincial Natural Science Foundation of China [2015JJ3035]
  3. China Postdoctoral Science Foundation [2015M580685]
  4. Anhui Province Natural Science Foundation of China [1608085MB30]

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This paper reported a two-photon fluorescent probe for mitochondrial H2O2 detection and imaging based on the incorporation of a sensing boronate ester and an organelle-targeting triphenylphosphonium moiety onto the carbazole fluorophore. The probe exhibits a fast turn on response, good selectivity toward H2O2 and high specificity for mitochondria.

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