4.2 Review

Wilms' tumor gene 1 in hematological malignancies: friend or foe?

Related references

Note: Only part of the references are listed.
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Summary: The study developed a helper epitope-containing WT1 protein vaccine and examined the effect of B. longum 420 and B. longum 420/2656 combination on the antitumor activity in a model of murine leukemia. The results showed that the B. longum 420/2656 combination group had significantly smaller tumor volume and higher WT1-specific CTL frequency. These findings suggest that the B. longum 420/2656 combination can further accelerate the antitumor activity relying on WT1-specific CTLs.

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Summary: In this study, high-avidity WT1-specific T cells were identified from the allogeneic T-cell repertoire of healthy donors. These T cells showed potent and specific anti-WT1 activity against newly identified WT1 peptides derived from primary leukemia and ovarian carcinoma samples. Additionally, T-cell clones with T-cell receptor (TCR) gene transfer showed antitumor reactivity against WT1-expressing solid tumor cell lines, acute myeloid leukemia (AML) blasts, and ovarian carcinoma patient samples. These findings suggest that these TCRs and naturally expressed WT1 peptides have potential for TCR gene transfer strategies in patients with WT1-expressing tumors, including AML and ovarian carcinoma.

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Wilms' tumor gene 1 is an independent prognostic factor for pediatric acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation

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