4.7 Article

Methadone Maintenance and QT-Interval: Prevalence and Risk Factors-Is It Effective to Switch Therapy to Levomethadone?

Related references

Note: Only part of the references are listed.
Review Biophysics

Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome

Clifford Tebay et al.

Summary: Drug-induced long QT syndrome is caused by drugs prolonging cardiac repolarization and increasing the risk of ventricular tachycardia. The primary target is the hERG potassium channel in the heart, but the risk can be adjusted in patients by various environmental and disease-related factors.

BIOPHYSICAL REVIEWS (2022)

Article Nursing

Rediscovery of Methadone to Improve Outcomes in Pain Management

Gloria Lai et al.

Summary: Methadone is not only used in opioid maintenance therapy but also serves as an excellent analgesic that enhances acute and chronic pain management. Its unique pharmacological profile provides important benefits in perioperative use, neuropathic pain, cancer, and noncancer pain.

JOURNAL OF PERIANESTHESIA NURSING (2022)

Review Clinical Neurology

Methadone in Pain Management: A Systematic Review

Verina Hanna et al.

Summary: This article reviewed 40 RCTs demonstrating the effectiveness of methadone in managing different types of pain. Methadone showed good analgesic effectiveness compared to morphine or fentanyl, with lower side effects and cost benefits. Further research is needed to establish its role in pain management.

JOURNAL OF PAIN (2021)

Article Pharmacology & Pharmacy

Methadone-associated QT interval prolongation in patients undergoing maintenance therapy in an urban opioid treatment program

Erika N. Titus-Lay et al.

Summary: This study aimed to investigate the incidence of QT interval prolongation among patients receiving maintenance methadone therapy in an urban opioid treatment program, and to explore the relationship with serum methadone concentrations. The results showed that approximately 15% of patients experienced QT interval prolongation, and there was a correlation between serum methadone concentrations and QTc intervals.

PHARMACOTHERAPY (2021)

Review Health Care Sciences & Services

Methadone Switching for Cancer Pain: A New Classification of Initiation Protocols, Based on a Critical Literature Review

Erwan Treillet et al.

Summary: This article reviewed and classified recent literature on methadone initiation protocols in cancer patients, identifying eight initiation types and summarizing three high-quality studies. The findings provide the latest information on methadone initiation protocols, with a recommendation for a maximal daily methadone dose of 100mg for MEDD <500mg when using ad libitum protocols. Further clinical research on this topic is needed.

JOURNAL OF PALLIATIVE MEDICINE (2021)

Review Health Care Sciences & Services

Measurement and Management of QT Interval Prolongation for General Physicians

Praveen Indraratna et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2020)

Review Clinical Neurology

Methadone for Pain Management: A Pharmacotherapeutic Review

Denise Kreutzwiser et al.

CNS DRUGS (2020)

Article Pharmacology & Pharmacy

QT length during methadone maintenance treatment: gene x dose interaction

El-Hadi Zerdazi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2019)

Article Substance Abuse

Opioid use disorder in Germany: healthcare costs of patients in opioid maintenance treatment

Jens Reimer et al.

SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY (2019)

Review Pharmacology & Pharmacy

Risk factors for QTc-prolongation: systematic review of the evidence

Eline Vandael et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2017)

Article Cardiac & Cardiovascular Systems

Prolonged QT Interval Diagnosis Suppression by a Widely Used Computerized ECG Analysis System

Anubhav Garg et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2013)

Review Multidisciplinary Sciences

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review

Eleftherios M. Kallergis et al.

SCIENTIFIC WORLD JOURNAL (2012)

Editorial Material Substance Abuse

(R)-methadone versus racemic methadone: what is best for patient care?

Elinore F. Mccance-Katz

ADDICTION (2011)

Article Pharmacology & Pharmacy

QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France

Aurelie Perrin-Terrin et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2011)

Article Medicine, General & Internal

Substitution of (R,S)-Methadone by (R)-Methadone Impact on QTc Interval

Nicolas Ansermot et al.

ARCHIVES OF INTERNAL MEDICINE (2010)

Article Pharmacology & Pharmacy

Drug- and non-drug-associated QT interval prolongation

Charlotte van Noord et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2010)

Review Pharmacology & Pharmacy

Cellular basis of drug-induced torsades de pointes

D. M. Roden

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Accurate electrocardiographic assessment of the QT interval: Teach the tangent

Pieter G. Postema et al.

HEART RHYTHM (2008)

Article Pharmacology & Pharmacy

Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers

C. B. Eap et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)

Review Multidisciplinary Sciences

hERG potassium channels and cardiac arrhythmia

MC Sanguinetti et al.

NATURE (2006)